PMID- 15057902
OWN - NLM
STAT- MEDLINE
DCOM- 20040426
LR  - 20071114
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 39
IP  - 4
DP  - 2004 Apr
TI  - HLA and cytokine gene polymorphisms are independently associated with responses 
      to hepatitis B vaccination.
PG  - 978-88
AB  - Variable immune responses to hepatitis B virus (HBV) infection and recombinant 
      HBV vaccines have been associated with polymorphisms in several genes within the 
      human leukocyte antigen (HLA) complex. Analyses of polymerase chain reaction 
      (PCR)-based genotyping data from 164 North American adolescents vaccinated with 
      recombinant HBV products confirmed that HLA-DRB1*07 (relative odds [RO] = 5.18, P 
      <.0001) and human immunodeficiency virus type 1 (HIV-1) infection (RO = 3.91, P 
      <.001) were both associated with nonresponse to full-dose vaccination. Further 
      associations were observed with single nucleotide polymorphisms (SNPs) at the IL2 
      and IL4 loci along with insertion/deletion variants at the IL12B locus (P 
      =.003-.01). Host genetic associations were independent of one another as well as 
      other HLA (A, B, C, and DQB1) and cytokine gene (IL4R, IL6, IL10, and TNF) 
      variants. Statistical adjustments for nongenetic factors (gender, ethnicity, age, 
      HIV-1 infection, and vaccination protocols) did not substantially alter the 
      strengths of the genetic relationships. The overall distribution pattern of 
      genetic variations was similar between the analyzed vaccinees and additional 
      adolescents (n = 292) from the same cohort. In conclusion, DRB1*07 (or a closely 
      linked allele) and immunoregulatory cytokine gene polymorphisms correlate with 
      variable immune response to recombinant HBV vaccines.
FAU - Wang, Chengbin
AU  - Wang C
AD  - Department of Epidemiology, University of Alabama at Birmingham, Birmingham, 
      Alabama, USA.
FAU - Tang, Jianming
AU  - Tang J
FAU - Song, Wei
AU  - Song W
FAU - Lobashevsky, Elena
AU  - Lobashevsky E
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Kaslow, Richard A
AU  - Kaslow RA
LA  - eng
GR  - AI1173/AI/NIAID NIH HHS/United States
GR  - AI41951/AI/NIAID NIH HHS/United States
GR  - HD32842/HD/NICHD NIH HHS/United States
GR  - U01 HD32830/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Cohort Studies
MH  - Cytokines/*genetics
MH  - HIV Seronegativity
MH  - HIV-1
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Hepatitis B Vaccines/*genetics/immunology
MH  - Hepatitis B, Chronic/genetics/immunology/*prevention & control
MH  - Heterozygote
MH  - Humans
MH  - Immunophenotyping
MH  - Multivariate Analysis
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide
EDAT- 2004/04/02 05:00
MHDA- 2004/04/27 05:00
CRDT- 2004/04/02 05:00
PHST- 2004/04/02 05:00 [pubmed]
PHST- 2004/04/27 05:00 [medline]
PHST- 2004/04/02 05:00 [entrez]
AID - 10.1002/hep.20142 [doi]
PST - ppublish
SO  - Hepatology. 2004 Apr;39(4):978-88. doi: 10.1002/hep.20142.