PMID- 15059566
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20131121
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 40
IP  - 2
DP  - 2004 Feb
TI  - [Oxidative damage and photoreceptor cell apoptosis in contusion injury of the 
      rabbit retina].
PG  - 118-21
AB  - OBJECTIVE: To study the mechanism of retina injury and photoreceptor apoptosis 
      after contusion as well as their triggering factor. METHODS: The rabbit retina 
      was injured by a 3 J energy contusion caused by a free falling iron bar hitting 
      the cornea. The morphologic changes of the retina were observed by light and 
      electron microscopes. Terminal deoxynucleotidyl transferase-mediated dUTP nick 
      end labeling (TUNEL) technique was used to assess apoptosis. The amount of the 
      malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the 
      retina were assayed and analyzed statistically. RESULTS: Apoptosis of 
      photoreceptors was present in retina contusion caused by a 3 J energy injury. 
      After contusion, the MDA level increased gradually. The activity of SOD increased 
      reflectively at first, then decreased markedly 3 days after the contusion, which 
      was parallel with the appearance of apoptotic photoreceptors. CONCLUSIONS: 
      Apoptosis is an important mechanism of retina contusion. Free oxygen radicals are 
      the important triggering factors for the apoptosis of photoreceptors in the 
      retina contusion of the rabbits.
FAU - An, Mei-xia
AU  - An MX
AD  - Department of Ophthalmology, Zhengzhou Railway Bureau Center Hospital, Zhengzhou 
      450052, China. xhl75751@sohu.com
FAU - Zhang, Xiao-fang
AU  - Zhang XF
FAU - Zhang, Jin-song
AU  - Zhang JS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 0 (Free Radicals)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Contusions/*pathology
MH  - Female
MH  - Free Radicals
MH  - Male
MH  - Malondialdehyde/analysis
MH  - Oxidation-Reduction
MH  - Oxygen/*metabolism
MH  - Photoreceptor Cells/*pathology
MH  - Rabbits
MH  - Retina/*injuries/metabolism/pathology
EDAT- 2004/04/03 05:00
MHDA- 2004/07/14 05:00
CRDT- 2004/04/03 05:00
PHST- 2004/04/03 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2004/04/03 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2004 Feb;40(2):118-21.