PMID- 15062172
OWN - NLM
STAT- MEDLINE
DCOM- 20040621
LR  - 20191108
IS  - 1538-4721 (Print)
IS  - 1538-4721 (Linking)
VI  - 1
IP  - 2
DP  - 2002
TI  - Early-stage endometrial cancer: is intravaginal radiation therapy alone 
      sufficient therapy?
PG  - 61-5
AB  - For half a century, adjuvant radiation therapy has been an important component in 
      the treatment of patients with early-stage endometrial cancer believed to be at 
      significant risk of local or regional recurrence. The widespread adoption of 
      up-front surgical treatment and staging, including nodal assessment, has raised 
      new questions about the need for and extent of postoperative adjuvant treatment. 
      Furthermore, in some institutions, even in the absence of complete surgical 
      staging, the extent of postoperative adjuvant treatment is being reassessed. 
      These developments have increased interest in the use of intravaginal 
      brachytherapy (IVRT) alone in selected patients whose major risk of recurrence is 
      at the vaginal cuff. The potential advantages of this approach include lower cost 
      and decreased acute and late toxicity. The use of IVRT alone in select patients 
      was examined through a review of the available literature. The authors conclude 
      that there is a subset of patients in whom adjuvant treatment with IVRT alone is 
      adequate. A clinical approach involving patient selection criteria is proposed 
      which suggests separate selection criteria based on whether or not complete 
      surgical staging information is available.
FAU - McCormick, Traci C
AU  - McCormick TC
AD  - Department of Radiation Oncology, Indiana University School of Medicine, 
      Indianapolis, IN, USA. tmccormi@iupui.edu
FAU - Cardenes, Higinia
AU  - Cardenes H
FAU - Randall, Marcus E
AU  - Randall ME
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Brachytherapy
JT  - Brachytherapy
JID - 101137600
SB  - IM
MH  - Endometrial Neoplasms/pathology/*radiotherapy
MH  - Female
MH  - Humans
MH  - Neoplasm Staging
MH  - Radiotherapy/methods
MH  - Vagina
RF  - 21
EDAT- 2004/04/06 05:00
MHDA- 2004/06/24 05:00
CRDT- 2004/04/06 05:00
PHST- 2001/08/16 00:00 [received]
PHST- 2002/01/31 00:00 [revised]
PHST- 2002/02/25 00:00 [accepted]
PHST- 2004/04/06 05:00 [pubmed]
PHST- 2004/06/24 05:00 [medline]
PHST- 2004/04/06 05:00 [entrez]
AID - S1538472102000120 [pii]
AID - 10.1016/s1538-4721(02)00012-0 [doi]
PST - ppublish
SO  - Brachytherapy. 2002;1(2):61-5. doi: 10.1016/s1538-4721(02)00012-0.