PMID- 15063091
OWN - NLM
STAT- MEDLINE
DCOM- 20040614
LR  - 20091119
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 149
IP  - 2
DP  - 2004 Apr 19
TI  - Fetal development of vomeronasal system in the goat.
PG  - 113-20
AB  - Our previous study morphologically revealed that the adult goat vomeronasal (VN) 
      system was different from the rodent and opossum one, and at least two types of 
      VN systems exist in mammals. However, it remains unknown whether the developments 
      in both types of VN systems are ontogenetically distinct and when the goat VN 
      system is established. In this study, we morphologically observed the fetal 
      development of the goat accessory olfactory bulb (AOB) and VN neuron. In the 
      fetus, Gi2-expressing VN terminals terminated at glomeruli throughout the AOB, 
      and no immunoreactivities for Go were detected in the nerve terminals reaching 
      into AOB. The layer structure of AOB rapidly developed in the latter half of 
      gestation. In the VN organ (VNO), at the middle stage of gestation, the dendritic 
      processes of VN neuron were exposed in the VN lumen, and scattered and thin 
      microvilli existed on the protrusion of the VN neuron. In the apical part of 
      dendritic processes, no clear vesicle existed. However, the immunohistochemistry 
      of an olfactory marker protein (OMP) revealed that a few VN neurons with OMP 
      exist in VN sensory epithelium (VSE) before birth, although marked 
      immunoreactivities were detected in adult VSE. Fetal VN neurons appeared to be 
      underdeveloped. These results suggest that the goat VN system is ontogenetically 
      distinct from the rodent and opossum VN systems, and is underdeveloped before 
      birth. The goat VN system will develop and mature during the early postnatal 
      period similar to the rodent and opossum VN systems.
FAU - Takigami, Shu
AU  - Takigami S
AD  - Department of Developmental Morphology, Tokyo Metropolitan Institute for 
      Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan.
FAU - Wakabayashi, Yoshihiro
AU  - Wakabayashi Y
FAU - Ohsako, Shunji
AU  - Ohsako S
FAU - Ohkura, Satoshi
AU  - Ohkura S
FAU - Okamura, Hiroaki
AU  - Okamura H
FAU - Ikai, Atsushi
AU  - Ikai A
FAU - Ichikawa, Masumi
AU  - Ichikawa M
FAU - Osada, Toshiya
AU  - Osada T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Axons/metabolism
MH  - Embryonic and Fetal Development/*physiology
MH  - Female
MH  - GTP-Binding Protein alpha Subunits, Gi-Go/metabolism
MH  - Goats
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Microscopy, Electron/methods
MH  - Neural Cell Adhesion Molecules/metabolism
MH  - Neurons/*physiology
MH  - Olfactory Bulb/cytology/embryology
MH  - Pregnancy
MH  - Vomeronasal Organ/*embryology/ultrastructure
EDAT- 2004/04/06 05:00
MHDA- 2004/06/15 05:00
CRDT- 2004/04/06 05:00
PHST- 2004/01/15 00:00 [accepted]
PHST- 2004/04/06 05:00 [pubmed]
PHST- 2004/06/15 05:00 [medline]
PHST- 2004/04/06 05:00 [entrez]
AID - S0165380604000471 [pii]
AID - 10.1016/j.devbrainres.2004.01.003 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2004 Apr 19;149(2):113-20. doi: 
      10.1016/j.devbrainres.2004.01.003.