PMID- 15063713
OWN - NLM
STAT- MEDLINE
DCOM- 20040512
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 563
IP  - 1-3
DP  - 2004 Apr 9
TI  - MDMA (Ecstasy) controls in concert a group of genes involved in GABA 
      neurotransmission.
PG  - 3-6
AB  - In several countries, 3,4-methylenedioxymethamphetamine (MDMA) is currently the 
      most abundant psychoactive recreational drug. MDMA induces numerous 
      neuropsychiatric behaviors, serotonergic neuron degeneration, programmed death of 
      cultured cells, hyperthermia and occasional fatality. Using gene expression 
      analysis in MDMA-treated mice, we identified changes in gamma-amino butyric acid 
      (GABA) transporters and synaptotagmins I and IV. Additional experiments showed 
      decreases in mRNAs encoding septin and dystrophin. Although belonging to 
      different gene families, it is striking that these four protein groups are 
      implicated in neurotransmission of GABA, a major inhibitory neurotransmitter 
      involved in thermoregulation. MDMA may control these genes in a combined fashion, 
      assigning GABA a pivotal role in MDMA activities.
FAU - Simantov, Rabi
AU  - Simantov R
AD  - Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, 
      Israel. rabi.simantov@weizmann.ac.il
FAU - Peng, Weiping
AU  - Peng W
LA  - eng
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Agents)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Gene Expression/*drug effects
MH  - Gene Expression Profiling
MH  - *Genes
MH  - Hallucinogens/pharmacology
MH  - Illicit Drugs/pharmacology
MH  - Mice
MH  - Models, Biological
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nerve Tissue Proteins/drug effects
MH  - RNA, Messenger/drug effects
MH  - Serotonin Agents/*pharmacology
MH  - Synaptic Transmission/*drug effects
MH  - gamma-Aminobutyric Acid/*drug effects
EDAT- 2004/04/06 05:00
MHDA- 2004/05/13 05:00
CRDT- 2004/04/06 05:00
PHST- 2004/02/16 00:00 [received]
PHST- 2004/02/24 00:00 [revised]
PHST- 2004/02/24 00:00 [accepted]
PHST- 2004/04/06 05:00 [pubmed]
PHST- 2004/05/13 05:00 [medline]
PHST- 2004/04/06 05:00 [entrez]
AID - S001457930400256X [pii]
AID - 10.1016/S0014-5793(04)00256-X [doi]
PST - ppublish
SO  - FEBS Lett. 2004 Apr 9;563(1-3):3-6. doi: 10.1016/S0014-5793(04)00256-X.