PMID- 1506452
OWN - NLM
STAT- MEDLINE
DCOM- 19920921
LR  - 20061115
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 12
IP  - 5
DP  - 1992 Sep
TI  - Intracerebral microdialysis of extracellular amino acids in the human epileptic 
      focus.
PG  - 873-6
AB  - Extracellular levels of aspartate (ASP), glutamate (GLU), serine (SER), 
      asparagine (ASN), glycine (GLY), threonine (THR), arginine (ARG), alanine (ALA), 
      taurine (TAU), tyrosine (TYR), phenylalanine (PHE), isoleucine (ILEU), and 
      leucine (LEU) were monitored by using intracerebral microdialysis in seven 
      patients with medically intractable epilepsy, undergoing epilepsy surgery. In 
      association with focal seizures, dramatic increases of the extracellular ASP, 
      GLU, GLY, and SER concentrations were observed. The other amino acids analyzed, 
      including TAU, showed small changes. The results support the hypothesis that ASP, 
      GLU, GLY, and possibly SER, play an important role in the mechanism of seizure 
      activity and seizure-related brain damage in the human epileptic focus.
FAU - Ronne-Engstrom, E
AU  - Ronne-Engstrom E
AD  - Department of Neurosurgery, University Hospital of Uppsala, Sweden.
FAU - Hillered, L
AU  - Hillered L
FAU - Flink, R
AU  - Flink R
FAU - Spannare, B
AU  - Spannare B
FAU - Ungerstedt, U
AU  - Ungerstedt U
FAU - Carlson, H
AU  - Carlson H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Amino Acids)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amino Acids/*metabolism
MH  - Brain/*metabolism
MH  - Child
MH  - Dialysis/methods
MH  - Epilepsies, Partial/*metabolism/physiopathology
MH  - Humans
MH  - Middle Aged
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1038/jcbfm.1992.119 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1992 Sep;12(5):873-6. doi: 10.1038/jcbfm.1992.119.