PMID- 15065649
OWN - NLM
STAT- MEDLINE
DCOM- 20041026
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 202
IP  - 3
DP  - 2004 Mar
TI  - The Tohoku Study of Child Development: A cohort study of effects of perinatal 
      exposures to methylmercury and environmentally persistent organic pollutants on 
      neurobehavioral development in Japanese children.
PG  - 227-37
AB  - Several birth cohort studies have shown adverse effects of perinatal exposures to 
      methylmercury (MeHg) and environmentally persistent organic pollutants (POPs). 
      These chemicals are ingested mainly through fish consumption, but little is known 
      about the hazardous effects in Japanese, whose fish consumption is high. The 
      present study, the Tohoku Study of Child Development, was designed to examine the 
      effects of perinatal exposures to MeHg, polychlorinated biphenyls (PCB), dioxins, 
      pesticides, and other chemicals in Japanese children. Six hundred eighty-seven 
      pregnant women were participated in this study with their written informed 
      consent. Maternal peripheral blood, cord blood, cord tissue, placenta, and breast 
      milk samples were collected for chemical analysis. Maternal hair was also taken 
      for MeHg analysis. Infants born at full term were assessed by neurobehavioral 
      tests: the Brazelton Neonatal Behavioral Assessment Scale at three days old, the 
      Kyoto Scale of Psychological Development and the Bayley Scales of Infant 
      Development at 7 and 18 months old, and the Fagan Test of Infant Intelligence at 
      7 months old. The children will be continuously followed up to ages 6-7 years. 
      Maternal food intake frequency, maternal IQ, socioeconomic status, and home 
      environment were assessed as covariates. The results of this cohort study will 
      allow us to evaluate associations between the neurobehavioral development of 
      children and perinatal exposures to MeHg and environmentally POPs in Japan.
FAU - Nakai, Kunihiko
AU  - Nakai K
AD  - Department of Environmental Health Sciences, Tohoku University Graduate School of 
      Medicine, Sendai 980-8575, Japan. nakaik@mail.tains.tohoku.ac.jp
FAU - Suzuki, Keita
AU  - Suzuki K
FAU - Oka, Tomoko
AU  - Oka T
FAU - Murata, Katsuyuki
AU  - Murata K
FAU - Sakamoto, Mineshi
AU  - Sakamoto M
FAU - Okamura, Kunihiro
AU  - Okamura K
FAU - Hosokawa, Toru
AU  - Hosokawa T
FAU - Sakai, Takeo
AU  - Sakai T
FAU - Nakamura, Tomoyuki
AU  - Nakamura T
FAU - Saito, Yoshinori
AU  - Saito Y
FAU - Kurokawa, Naoyuki
AU  - Kurokawa N
FAU - Kameo, Satomi
AU  - Kameo S
FAU - Satoh, Hiroshi
AU  - Satoh H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Environmental Pollutants)
RN  - 0 (Methylmercury Compounds)
SB  - IM
MH  - Animals
MH  - *Child Development
MH  - Cohort Studies
MH  - Developmental Disabilities/*chemically induced
MH  - Diet
MH  - Environmental Pollutants/metabolism/*pharmacology/*toxicity
MH  - Female
MH  - Fishes
MH  - Humans
MH  - Infant
MH  - Japan
MH  - Methylmercury Compounds/metabolism/*pharmacology/*toxicity
MH  - Milk, Human/chemistry
MH  - Nervous System/*drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Psychomotor Performance
MH  - Surveys and Questionnaires
EDAT- 2004/04/07 05:00
MHDA- 2004/10/27 09:00
CRDT- 2004/04/07 05:00
PHST- 2004/04/07 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2004/04/07 05:00 [entrez]
AID - 10.1620/tjem.202.227 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2004 Mar;202(3):227-37. doi: 10.1620/tjem.202.227.