PMID- 15066154
OWN - NLM
STAT- MEDLINE
DCOM- 20040528
LR  - 20161124
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 19
IP  - 6
DP  - 2004 Mar
TI  - Inactivation of the olfactory amygdala prevents the endocrine response to male 
      odour in anoestrus ewes.
PG  - 1581-90
AB  - Our aim was to study the role of the olfactory amygdala (medial and cortical 
      nuclei) and the ventromedial nucleus of the hypothalamus (VMN) in the ability of 
      the male odour or live males to induce a release of luteinizing hormone in 
      anoestrus ewes. To achieve this, we temporarily blocked the activity of these 
      structures by localized retrodialysis administration of the anaesthetic 
      lidocaine. The effect of ram odour on the secretion of luteinizing hormone was 
      completely blocked by inactivation of the cortical nucleus of the amygdala. In 
      contrast, inactivation of part of the accessory olfactory system (the medial 
      nucleus of the amygdala or the VMN) had no effect. In the presence of the male, 
      lidocaine never impaired the endocrine response of the ewes. These results show 
      that modulation of reproduction by the sexual partner even through pheromonal 
      cues does not occur via the direct circuit of the accessory system. On the 
      contrary, the cortical nucleus of the amygdala is absolutely necessary for the 
      treatment of and/or the response to the male olfactory signal but this structure 
      can be bypassed when other sensory cues are available.
FAU - Gelez, H
AU  - Gelez H
AD  - Station de Physiologie de la Reproduction et des Comportements, UMR 6073, 
      INRA/CNRS/Universite de Tours, 37380 Nouzilly, France.
FAU - Archer, E
AU  - Archer E
FAU - Chesneau, D
AU  - Chesneau D
FAU - Magallon, T
AU  - Magallon T
FAU - Fabre-Nys, C
AU  - Fabre-Nys C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 98PI200987 (Lidocaine)
SB  - IM
MH  - Amygdala/anatomy & histology/drug effects/*physiology
MH  - *Anestrus
MH  - Animals
MH  - Behavior, Animal
MH  - Chi-Square Distribution
MH  - Endocrine System/drug effects/*physiology
MH  - Female
MH  - Goats
MH  - Lidocaine/pharmacology
MH  - Luteinizing Hormone/*blood
MH  - Male
MH  - Microdialysis/methods
MH  - *Odorants
MH  - Olfactory Pathways/drug effects
MH  - Radioimmunoassay/methods
MH  - Time Factors
MH  - Ventromedial Hypothalamic Nucleus/drug effects/physiology
EDAT- 2004/04/07 05:00
MHDA- 2004/05/29 05:00
CRDT- 2004/04/07 05:00
PHST- 2004/04/07 05:00 [pubmed]
PHST- 2004/05/29 05:00 [medline]
PHST- 2004/04/07 05:00 [entrez]
AID - EJN3261 [pii]
AID - 10.1111/j.1460-9568.2004.03261.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2004 Mar;19(6):1581-90. doi: 10.1111/j.1460-9568.2004.03261.x.