PMID- 15066323
OWN - NLM
STAT- MEDLINE
DCOM- 20040630
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 150
IP  - 2
DP  - 2004 Apr 15
TI  - Chromosomal insertion involving MLL in childhood acute myeloblastic leukemia 
      (M4).
PG  - 153-5
AB  - Recurrent chromosomal rearrangements involving the 11q23 region have been 
      described in various hematologic malignancies. Among these rearrangements, 
      translocations are the most common mechanism involving the mixed lineage leukemia 
      gene (MLL). Few cases of insertion have been reported and, to our knowledge, none 
      of them involved MLL and chromosome 1. We report a complex karyotype in a 
      childhood acute myelomonocytic leukemia (AML M4) involving the 11q23 region with 
      an insertion between chromosomes 1 and 11 in addition to a translocation between 
      chromosomes 11 and 22. This translocation was clarified by fluorescence in situ 
      hybridization (FISH) analysis: 46,XY,ins(1;11)(q22 approximately 
      q23;q13q23),t(11;22)(q13;q11 approximately q12). This finding also underlines the 
      complementary contribution of conventional cytogenetic and FISH analysis to 
      detect karyotypic complex abnormalities.
FAU - Lafay-Cousin, Lucie
AU  - Lafay-Cousin L
AD  - INSERM Unite 524, Institut de Recherches sur le Cancer de Lille, 1 place de 
      Verdun, 59000 Lille Cedex, France.
FAU - Soenen, Valerie
AU  - Soenen V
FAU - Mazingue, Francoise
AU  - Mazingue F
FAU - Preudhomme, Claude
AU  - Preudhomme C
FAU - Lai, Jean-Luc
AU  - Lai JL
FAU - Andrieux, Joris
AU  - Andrieux J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Transposable Elements)
SB  - IM
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - DNA Transposable Elements/*genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Leukemia, Myelomonocytic, Acute/*genetics
MH  - Male
EDAT- 2004/04/07 05:00
MHDA- 2004/07/01 05:00
CRDT- 2004/04/07 05:00
PHST- 2003/06/03 00:00 [received]
PHST- 2003/08/11 00:00 [revised]
PHST- 2003/08/12 00:00 [accepted]
PHST- 2004/04/07 05:00 [pubmed]
PHST- 2004/07/01 05:00 [medline]
PHST- 2004/04/07 05:00 [entrez]
AID - S0165460803003418 [pii]
AID - 10.1016/j.cancergencyto.2003.08.006 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Apr 15;150(2):153-5. doi: 
      10.1016/j.cancergencyto.2003.08.006.