PMID- 15066325
OWN - NLM
STAT- MEDLINE
DCOM- 20040630
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 150
IP  - 2
DP  - 2004 Apr 15
TI  - Uncommon karyotypic abnormality, t(11;19)(q23;p13.3), in a patient with blastic 
      phase of chronic myeloid leukemia.
PG  - 159-63
AB  - We describe unusual cytogenetic findings in a 33-year-old male with blastic phase 
      of Philadelphia chromosome (Ph)-positive chronic myeloid leukemia. In addition to 
      the t(9;22)(q34;q11), which was detected in all metaphases, a t(11;19)(q23;p13.3) 
      was also identified as an evolutional change in all 20 metaphases. Fluorescence 
      in situ hybridization (FISH) analysis showed that fusion signals of the ABL/BCR 
      probes were found in 95% of blastic cells. Southern blotting and FISH analysis 
      also revealed involvement of the MLL gene on 11q23. Clinical course was 
      aggressive and the patient responded poorly to therapy. These findings suggest an 
      association between Ph and 11q23 with poor prognosis, and that 
      t(11;19)(q23;p13.3) was the essential pathogenic factor in our case.
FAU - Suzuki, Keijiro
AU  - Suzuki K
AD  - Department of Hematology/Oncology, Iwate Medical University, 19-1 Uchimaru, 
      Morioka, Iwate 020-8505, Japan. ksuzuki-th@umin.ac.jp
FAU - Sugawara, Takeshi
AU  - Sugawara T
FAU - Kowata, Shugo
AU  - Kowata S
FAU - Utsugizawa, Taiju
AU  - Utsugizawa T
FAU - Ito, Shigeki
AU  - Ito S
FAU - Murai, Kazunori
AU  - Murai K
FAU - Ishida, Yoji
AU  - Ishida Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Adult
MH  - Antigens, CD/genetics
MH  - Blast Crisis/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 19/*genetics
MH  - Humans
MH  - Immunophenotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/*pathology
MH  - Male
MH  - Translocation, Genetic/*genetics
EDAT- 2004/04/07 05:00
MHDA- 2004/07/01 05:00
CRDT- 2004/04/07 05:00
PHST- 2003/07/09 00:00 [received]
PHST- 2003/08/25 00:00 [revised]
PHST- 2003/09/04 00:00 [accepted]
PHST- 2004/04/07 05:00 [pubmed]
PHST- 2004/07/01 05:00 [medline]
PHST- 2004/04/07 05:00 [entrez]
AID - S016546080300387X [pii]
AID - 10.1016/j.cancergencyto.2003.09.005 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Apr 15;150(2):159-63. doi: 
      10.1016/j.cancergencyto.2003.09.005.