PMID- 15068623
OWN - NLM
STAT- MEDLINE
DCOM- 20041012
LR  - 20221207
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 14
IP  - 2
DP  - 2004 Feb
TI  - A polymorphism of interferon-gamma gene associated with changes of 
      anti-thyrotropin receptor antibodies induced by antithyroid drug treatment for 
      Graves' disease in Japanese patients.
PG  - 93-7
AB  - Graves' disease (GD) is an autoimmune disorder with genetic predisposition. 
      Interferon-gamma (IFN-gamma) is an important mediator of inflammatory and immune 
      responses. The aim of the present study was to investigate whether the 
      polymorphism of IFN-gamma gene is associated with the development of GD or with 
      clinical course during the antithyroid drug therapy. We have studied the CA 
      repeat polymorphisms in the first intron of IFN gamma gene in Japanese patients 
      with GD (n = 162) and healthy control subjects without antithyroid autoantibodies 
      or family history of autoimmune disorders (n = 133). There was no difference in 
      allele frequency of IFN-gamma gene polymorphism between patients with GD and 
      control subjects. However, the allele 4 (15 CA repeats) frequency was 
      significantly greater in patients whose antithyrotropin receptor antibody (TRAb) 
      became negative within 3 years by antithyroid drug treatment than those with 
      consistently positive TRAb for more than 3 years (34.1% vs. 15.7%, chi2 = 8.545, 
      p = 0.0035, pc = 0.049). The in vitro production of IFN-gamma by concanavalin 
      A-stimulated peripheral blood mononuclear cells was significantly smaller in 
      control subjects with the allele 4 compared to those with the other alleles. In 
      conclusions, the CA repeat polymorphism of the IFN-gamma gene might be associated 
      with the outcome of anti-thyroid drug treatment.
FAU - Fukutani, Tomoka
AU  - Fukutani T
AD  - Department of Endocrinology and Metabolism, Kurame University School of Medicine, 
      Kurame, Japan.
FAU - Hiromatsu, Yuji
AU  - Hiromatsu Y
FAU - Kaku, Hiroo
AU  - Kaku H
FAU - Miyake, Ikuyo
AU  - Miyake I
FAU - Mukai, Tokunori
AU  - Mukai T
FAU - Imamura, Yoichi
AU  - Imamura Y
FAU - Kohno, Shusuke
AU  - Kohno S
FAU - Takane, Naoko
AU  - Takane N
FAU - Shoji, Shingo
AU  - Shoji S
FAU - Otabe, Shuichi
AU  - Otabe S
FAU - Yamada, Kentaro
AU  - Yamada K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Antithyroid Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Thyrotropin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 8J337D1HZY (Cytosine)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Adenine
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antithyroid Agents/*therapeutic use
MH  - *Asian People
MH  - Autoantibodies/*blood
MH  - Case-Control Studies
MH  - Cytosine
MH  - Dinucleotide Repeats
MH  - Female
MH  - Gene Frequency
MH  - Graves Disease/*drug therapy/immunology/physiopathology
MH  - Humans
MH  - Interferon-gamma/biosynthesis/*genetics
MH  - Introns/genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Receptors, Thyrotropin/*immunology
EDAT- 2004/04/08 05:00
MHDA- 2004/10/13 09:00
CRDT- 2004/04/08 05:00
PHST- 2004/04/08 05:00 [pubmed]
PHST- 2004/10/13 09:00 [medline]
PHST- 2004/04/08 05:00 [entrez]
AID - 10.1089/105072504322880328 [doi]
PST - ppublish
SO  - Thyroid. 2004 Feb;14(2):93-7. doi: 10.1089/105072504322880328.