PMID- 15070966
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20041117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 89
IP  - 4
DP  - 2004 Apr
TI  - Non-islet origin of pancreatic islet cell tumors.
PG  - 1934-8
AB  - The histogenesis of pancreatic islet cell tumors was investigated by 
      morphological identification of putative precursor lesions in pancreatic tissue 
      from patients with multiple endocrine neoplasia type 1 (MEN1), tissue 
      microdissection, and genetic analysis. MEN1 mutation and absence of the MEN1 
      wild-type allele in different precursor lesions strongly suggest that pancreatic 
      islet cell tumors are derived from the ductal/acinar system but not from 
      pancreatic islet tissue. Pluripotent cells within the exocrine pancreas appear 
      capable of formation into small atypical accumulations of MEN1-deficient cells 
      with both exocrine and endocrine phenotype. The findings suggest presence of 
      multiple developmental aberrations in MEN1 pancreas that potentially serve as 
      precursor material for neuroendocrine tumors.
FAU - Vortmeyer, Alexander O
AU  - Vortmeyer AO
AD  - Molecular Pathogenesis Laboratory, Surgical Neurology Branch, National Institute 
      of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, 
      Maryland 20892, USA. vortmeyera@ninds.nih.gov
FAU - Huang, Steve
AU  - Huang S
FAU - Lubensky, Irina
AU  - Lubensky I
FAU - Zhuang, Zhengping
AU  - Zhuang Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adenoma, Islet Cell/*etiology/pathology
MH  - Alleles
MH  - Cell Differentiation
MH  - Germ-Line Mutation
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*complications/*genetics
MH  - Pancreas/metabolism/pathology
MH  - Pancreatic Neoplasms/*etiology/*genetics/pathology
MH  - Pluripotent Stem Cells/metabolism/pathology
MH  - Precancerous Conditions/pathology
MH  - Proto-Oncogene Proteins/*genetics
EDAT- 2004/04/09 05:00
MHDA- 2004/05/12 05:00
CRDT- 2004/04/09 05:00
PHST- 2004/04/09 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2004/04/09 05:00 [entrez]
AID - 10.1210/jc.2003-031575 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2004 Apr;89(4):1934-8. doi: 10.1210/jc.2003-031575.