PMID- 1507170
OWN - NLM
STAT- MEDLINE
DCOM- 19920918
LR  - 20190509
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 33 Suppl
DP  - 1992 Mar
TI  - Factors that determine the in vivo dose-response relationship for stable 
      chromosome aberrations in A-bomb survivors.
PG  - 206-14
AB  - An overview is given of the dose-response relationship for stable chromosome 
      aberrations (i.e., translocations and inversions) in the peripheral blood 
      lymphocytes of A-bomb survivors in Hiroshima. Special emphasis is placed on (i) 
      the overdispersion of survivor cases with either unexpectedly high or low 
      aberration frequencies relative to the estimated DS86 kerma values assigned to 
      individual survivors, termed "cytogenetic outliers", and (ii) the correlation of 
      chromosome aberration frequencies with other biological endpoints, such as acute 
      radiation symptoms (severe epilation). A new molecular biological technique, 
      known as fluorescence in situ hybridization (FISH) with composite, 
      whole-chromosome probes to paint differentially the target chromosomes, has 
      facilitated rapid, efficient, and extensive scoring of translocation-type 
      chromosome aberrations in which the target chromosomes are involved. Using this 
      methodology, the observed findings on translocation frequencies in A-bomb 
      survivors have shown that the frequency of stable chromosome aberrations, which 
      have persisted for years without change in frequency in irradiated persons, is 
      indeed useful as an indicator for biological dosimetry.
FAU - Awa, A A
AU  - Awa AA
AD  - Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan.
FAU - Nakano, M
AU  - Nakano M
FAU - Ohtaki, K
AU  - Ohtaki K
FAU - Kodama, Y
AU  - Kodama Y
FAU - Lucas, J
AU  - Lucas J
FAU - Gray, J
AU  - Gray J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosomes/*radiation effects
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - Lymphocytes/*radiation effects/ultrastructure
MH  - *Nuclear Warfare
RF  - 13
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - 10.1269/jrr.33.supplement_206 [doi]
PST - ppublish
SO  - J Radiat Res. 1992 Mar;33 Suppl:206-14. doi: 10.1269/jrr.33.supplement_206.