PMID- 15072502
OWN - NLM
STAT- MEDLINE
DCOM- 20040830
LR  - 20190906
IS  - 0301-1623 (Print)
IS  - 0301-1623 (Linking)
VI  - 35
IP  - 2
DP  - 2003
TI  - The effects of human chorionic gonadotropin treatment on the contralateral side 
      in unilateral testicular torsion.
PG  - 237-45
AB  - BACKGROUND/PURPOSE: Unilateral testicular torsion can cause histologic damage, 
      consisting of aspermatogenesis and tubular atrophy, in the contralateral testis 
      human chorionic gonadotropin (HCG) treatment is widely used in undescended 
      testis, and has been shown to improve histomorphometric alterations beside the 
      testicular descent. However, the role of HCG in testicular torsion has not been 
      investigated before. Therefore, this experimental study was conducted to evaluate 
      the effects of HCG treatment on contralateral testicular histology and function 
      in unilateral testicular torsion. METHODS: Forty adult male Wistar rats were 
      randomized into 4 groups: SHAM, SHAM+HCG, TORSION, and TORSION+HCG. Torsion was 
      created by twisting the righ testis 720 degrees and maintained by fixing it to 
      the scrotum. HCG treatment started 24 hours after the torsion at a dose of 100 
      IU/kg, twice weekly for three weeks. Left orchiectomy was performed one month 
      after the torsion and removed testes were immersed in Bouin's fixative for 
      histopathological evaluation. Mean seminiferous tubule diameter (MSTD) was 
      measured and Johnsen's score was calculated. Blood samples were taken for 
      assaying serum testosteron level. RESULTS: Unilateral testicular torsion resulted 
      in a significant decrease in spermatogenesis and MSTD on the contralateral side. 
      Serum testosteron level was also reduced. HCG treatment improved these parameters 
      in the contralateral 'untwisted' testis beside the serum testosteron. 
      CONCLUSIONS: Our data demonstrates that unilateral testicular torsion adversely 
      effects its counterpart. HCG treatment improves contralateral histomorphometric 
      alterations and serum testosteron in unilateral torsion.
FAU - Savas, Cagri
AU  - Savas C
AD  - Suleyman Demirel University Medical School, Department of Pediatric Surgery, 
      Isparta, Turkey. cagrisavas@yahoo.com
FAU - Ozguner, Meltem
AU  - Ozguner M
FAU - Ozguner, Faruk
AU  - Ozguner F
FAU - Delibas, Namik
AU  - Delibas N
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Chorionic Gonadotropin)
SB  - IM
MH  - Animals
MH  - Chorionic Gonadotropin/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Spermatic Cord Torsion
MH  - Testis/*drug effects/pathology
EDAT- 2004/04/10 05:00
MHDA- 2004/08/31 05:00
CRDT- 2004/04/10 05:00
PHST- 2004/04/10 05:00 [pubmed]
PHST- 2004/08/31 05:00 [medline]
PHST- 2004/04/10 05:00 [entrez]
AID - 10.1023/b:urol.0000020288.58686.5b [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2003;35(2):237-45. doi: 10.1023/b:urol.0000020288.58686.5b.