PMID- 15072812
OWN - NLM
STAT- MEDLINE
DCOM- 20040628
LR  - 20131121
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 74
IP  - 1
DP  - 2004 Apr 9
TI  - Baclofen prevents MDMA-induced rise in core body temperature in rats.
PG  - 89-96
AB  - A number of deaths have been attributed to severe hyperthermia resulting from the 
      ingestion of 3,4-methylenedioxymethamphetamine (MDMA). The mechanisms underlying 
      these events are unclear. In an attempt to further advance our understanding of 
      these mechanism the present study investigated the effects of the selective 
      GABA(A) agonist muscimol and the GABA(B) agonist baclofen on MDMA-induced 
      responses in the rat. Baclofen at 1 and 3 mg/kg and muscimol at 0.3 and 1 mg/kg 
      administered alone had no effect on heart rate, core body temperature or 
      spontaneous locomotor activity as measured by radiotelemetry. MDMA at 15 mg/kg 
      produced a significant increase in heart rate, body temperature and locomotor 
      activity (P < 0.005) which were unaffected by prior treatment with muscimol. In 
      contrast, prior treatment with baclofen (3 mg/kg) resulted in MDMA causing a 
      sustained lowering of body temperature (P < 0.05), with no effect on heart rate 
      and a small transient delay in the increase in locomotor activity. Baclofen 
      pretreatment (3 mg/kg) not only prolonged the time taken for animals to reach a 
      core body temperature of 40 degrees C (P < 0.001), but also reduced the 
      percentage of rats attaining a core body temperature of 40 degrees C. These data 
      suggest that stimulation of GABA(B) receptors may provide a mechanism for the 
      treatment of MDMA-induced hyperthermia.
FAU - Bexis, Sotiria
AU  - Bexis S
AD  - Department of Clinical & Experimental Pharmacology, University of Adelaide, 
      Adelaide, SA 5005, Australia.
FAU - Phillis, Benjamin D
AU  - Phillis BD
FAU - Ong, Jennifer
AU  - Ong J
FAU - White, Jason M
AU  - White JM
FAU - Irvine, Rodney J
AU  - Irvine RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - H789N3FKE8 (Baclofen)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Baclofen/*pharmacology
MH  - Body Temperature/*drug effects/physiology
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2004/04/10 05:00
MHDA- 2004/06/29 05:00
CRDT- 2004/04/10 05:00
PHST- 2003/04/24 00:00 [received]
PHST- 2003/12/09 00:00 [revised]
PHST- 2003/12/12 00:00 [accepted]
PHST- 2004/04/10 05:00 [pubmed]
PHST- 2004/06/29 05:00 [medline]
PHST- 2004/04/10 05:00 [entrez]
AID - S0376871603003387 [pii]
AID - 10.1016/j.drugalcdep.2003.12.004 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2004 Apr 9;74(1):89-96. doi: 
      10.1016/j.drugalcdep.2003.12.004.