PMID- 15077132
OWN - NLM
STAT- MEDLINE
DCOM- 20050302
LR  - 20140728
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 33
IP  - 11
DP  - 2004 Jun
TI  - Impact of HLA matching on outcome of hematopoietic stem cell transplantation in 
      children with inherited diseases: a single-center comparative analysis of 
      genoidentical, haploidentical or unrelated donors.
PG  - 1089-95
AB  - Hematological inherited diseases can be cured by hematopoietic stem cell 
      transplantation (HSCT) from an human leukocyte antigen (HLA)-identical sibling 
      donor (MSD), but the outcome of unrelated donors (URD) or haploidentical donors 
      (HMD) has been a cause of concern. In all, 94 children affected with inherited 
      diseases underwent HSCT at a single center using MSD (group A, n=31), URD (group 
      B, n=23) or HMD (group C, n=40). There was no difference in the rate of 
      engraftment or in the incidence of grades III-IV acute graft-versus-host disease 
      (GVHD) between the groups. Survival rate was 80.6% in group A, 62.5% in group B 
      and 47.5% in group C (P=0.023). In group B, survival rate was 73.7% in the 
      subgroup with zero or one class I mismatch, and 25% in the subgroup with two or 
      more class I mismatches (P=0.04). In group C, survival rate was 83.3% in the 
      9/10-identical subgroup, 64.3% in the seven or 8/10 subgroup, and 25% in the five 
      or 6/10 subgroup (P=0.0007). Thus, engraftment, incidence of GVHD and survival 
      are similar in recipients of grafts from MSD, URD with 0-1 class I-mismatch, or 
      HMD with at least 7/10 HLA matches. The low success of HSCT using more disparate 
      donors suggests reserving them for patients with very poor prognosis.
CI  - Copyright 2004 Nature Publishing Group
FAU - Caillat-Zucman, S
AU  - Caillat-Zucman S
AD  - Laboratory of Immunology, Hopital Necker, Paris, France. caillat@necker.fr
FAU - Le Deist, F
AU  - Le Deist F
FAU - Haddad, E
AU  - Haddad E
FAU - Gannage, M
AU  - Gannage M
FAU - Dal Cortivo, L
AU  - Dal Cortivo L
FAU - Jabado, N
AU  - Jabado N
FAU - Hacein-Bey-Abina, S
AU  - Hacein-Bey-Abina S
FAU - Blanche, S
AU  - Blanche S
FAU - Casanova, J-L
AU  - Casanova JL
FAU - Fischer, A
AU  - Fischer A
FAU - Cavazzana-Calvo, M
AU  - Cavazzana-Calvo M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Genetic Diseases, Inborn/complications/mortality/*therapy
MH  - Genotype
MH  - Graft Survival/immunology
MH  - Graft vs Host Disease/immunology
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects/mortality/statistics & 
      numerical data
MH  - Histocompatibility/*genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Opportunistic Infections/immunology
MH  - Survival Analysis
MH  - Tissue Donors
MH  - Transplantation, Homologous
MH  - Transplantation, Isogeneic
MH  - Treatment Outcome
EDAT- 2004/04/13 05:00
MHDA- 2005/03/03 09:00
CRDT- 2004/04/13 05:00
PHST- 2004/04/13 05:00 [pubmed]
PHST- 2005/03/03 09:00 [medline]
PHST- 2004/04/13 05:00 [entrez]
AID - 1704510 [pii]
AID - 10.1038/sj.bmt.1704510 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2004 Jun;33(11):1089-95. doi: 10.1038/sj.bmt.1704510.