PMID- 15077908
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20191108
IS  - 1590-8658 (Print)
IS  - 1590-8658 (Linking)
VI  - 36 Suppl 1
DP  - 2004 Feb
TI  - The phenotype of gut endocrine tumours.
PG  - S26-30
AB  - Endocrine tumours of gut and pancreas tract are rare entities originating from 
      cells of the diffuse endocrine system. The endocrine phenotype is assessed by the 
      expression of general and specific endocrine markers. General endocrine markers 
      associate to organelles like large dense core vesicles (e.g. chromogranin A) and 
      small synaptic-like vesicles (e.g. synaptophysin), or to the cytosol, like neuron 
      specific enolase and protein gene product 9.5 (PGP9.5). The specific markers 
      correspond to the hormones produced by tumour cells. Two major categories of 
      endocrine tumours are identified as (i) well-differentiated and (ii) poorly 
      differentiated neoplasms. Well-differentiated tumours/carcinomas (also known as 
      carcinoids) express all general markers of endocrine differentiation and various 
      hormones. Poorly differentiated endocrine carcinomas lack large dense core 
      vesicles markers (chromogranin A), while widely express synaptophysin and cytosol 
      endocrine markers. The clinical behaviour of endocrine tumours spans from benign 
      to low-grade malignant for well-differentiated tumours/carcinomas to high grade 
      malignant for poorly differentiated carcinomas. The Multiple Endocrine Neoplasia 
      type 1 syndrome (MEN1) gene is involved in the genesis of a proportion of both 
      well- and poorly differentiated sporadic tumours. p53 gene abnormality appears as 
      restricted to poorly differentiated endocrine carcinomas.
FAU - Rindi, G
AU  - Rindi G
AD  - Department of Pathology and Laboratory Medicine, University of Parma, Via Gramsci 
      14, I-43100 Parma, Italy. guido.rindi@unipr.it
FAU - Ubiali, A
AU  - Ubiali A
FAU - Villanacci, V
AU  - Villanacci V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Dig Liver Dis
JT  - Digestive and liver disease : official journal of the Italian Society of 
      Gastroenterology and the Italian Association for the Study of the Liver
JID - 100958385
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - *Endocrine Gland Neoplasms/classification/genetics
MH  - *Gastrointestinal Neoplasms/classification/genetics
MH  - Humans
MH  - Phenotype
RF  - 54
EDAT- 2004/04/14 05:00
MHDA- 2004/06/02 05:00
CRDT- 2004/04/14 05:00
PHST- 2004/04/14 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2004/04/14 05:00 [entrez]
AID - S1590-8658(03)00653-4 [pii]
AID - 10.1016/j.dld.2003.11.010 [doi]
PST - ppublish
SO  - Dig Liver Dis. 2004 Feb;36 Suppl 1:S26-30. doi: 10.1016/j.dld.2003.11.010.