PMID- 15080492
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20061115
IS  - 1078-0297 (Print)
IS  - 1078-0297 (Linking)
VI  - 112
IP  - 1-4
DP  - 2002
TI  - Plasma cytokines as predictors of coronary heart disease.
PG  - 5-15
AB  - BACKGROUND AND OBJECTIVE: Growing body of evidence explicitly suggests the 
      significant role of inflammatory processes in vascular diseases related to 
      atherosclerosis. Monocytes, present in every phase of atherogenesis, are the 
      principal cells accumulating in atherosclerotic plaque. Monocyte Chemotactic 
      Protein 1 (MCP-1) seems to influence firm adherence of rolling monocytes and 
      infiltration into the artery wall. Although the significant meaning of 
      inflammation in atherogenesis has been proved, potential role of antiinflammatory 
      cytokines remains unknown. Interleukin 10 (IL-10) is a major cytokine of 
      pleiotropic antiinflammatory function known to exert inhibitory effects on 
      monocytes. Recent data emerging from clinical and pathological studies suggest 
      important role of thrombosis and fibrinolytic disorders in atherosclerosis 
      complications especially in coronary heart disease (CHD). Individuals with 
      greater Plasminogen Activator Inhibitor 1 (PAI-1) level are believed to be more 
      susceptible to cardiovascular disease. METHODS: In our study we measured the 
      plasma levels of MCP-1, IL-10 and PAI-1 in 10 patients with stable angina and 10 
      healthy subjects. We also estimated its mutual correlations. The plasma levels of 
      MCP-1, IL-10 and PAI-1 were determined with R&D kits (ELISA). RESULTS: Plasma 
      levels of MCP-1 were significantly higher (261.5+/-40.7 pg/mL vs 73.3+/-3.05 
      pg/mL; p<0.0002) and also levels of PAI-1 were higher (79.36+/-5.8 ng/mL vs 
      35.88+/-1.38 ng/mL; p<0.0001) in patients with SA compared with the healthy 
      control subjects. Whereas plasma levels of IL-10 were lower (11.6+/-0.5 pg/mL vs 
      16.5+/-0.4 pg/mL; p<0.0001) compared with control group and correlated with both 
      MCP-1 plasma level (r=-0.67; p<0.0015) and PAI-1 concentration (r=-0.69; 
      p<0.0008). CONCLUSION: The data obtained confirm the predictive role of cytokines 
      in patients with stable coronary heart disease. The negative correlation of 
      anti-inflammatory IL-10 and PAI-1 was also found.
FAU - Okopien, B
AU  - Okopien B
AD  - Department of Clinical Pharmacology, Medical University of Silesia, Katowice, 
      Poland.
FAU - Haberka, M
AU  - Haberka M
FAU - Cwalina, L
AU  - Cwalina L
FAU - Kowalski, J
AU  - Kowalski J
FAU - Belowski, D
AU  - Belowski D
FAU - Madej, A
AU  - Madej A
FAU - Zielinski, M
AU  - Zielinski M
FAU - Krysiak, R
AU  - Krysiak R
FAU - Labuzek, K
AU  - Labuzek K
FAU - Kalina, Z
AU  - Kalina Z
FAU - Herman, Z S
AU  - Herman ZS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Res Commun Mol Pathol Pharmacol
JT  - Research communications in molecular pathology and pharmacology
JID - 9437512
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Angina Pectoris/blood
MH  - Chemokine CCL2/blood
MH  - Coronary Disease/*diagnosis
MH  - Cytokines/*blood
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Interleukin-10/blood
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Predictive Value of Tests
EDAT- 2004/04/15 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/04/15 05:00
PHST- 2004/04/15 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/04/15 05:00 [entrez]
PST - ppublish
SO  - Res Commun Mol Pathol Pharmacol. 2002;112(1-4):5-15.