PMID- 15080833
OWN - NLM
STAT- MEDLINE
DCOM- 20040809
LR  - 20171116
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 5
DP  - 2004 May
TI  - A promoter polymorphism in the CD14 gene is associated with elevated levels of 
      soluble CD14 but not with IgE or atopic diseases.
PG  - 520-5
AB  - BACKGROUND: A polymorphism in the promoter region of the CD14 gene, C-159T, has 
      been shown to be associated with increased levels of soluble CD14 (sCD14) and 
      decreased serum immunoglobulin E (IgE) and the expression of a more severe atopic 
      phenotype in previous studies. METHODS: To test if these associations are 
      consistently found in different populations and different age groups, we 
      genotyped 2048 children of different age groups as well as 888 adults from 
      different regions of Germany for the CD14 C-159T polymorphism. RESULTS: While an 
      association between this promoter polymorphism and levels of sCD14 could be 
      confirmed in our study population (CC: 1017 ng/ml vs TT: 1370 ng/ml, P = 0.03), 
      no association between CD14 C-159T genotypes and IgE levels or the prevalence of 
      atopic diseases was seen. CONCLUSIONS: The lack of association between CD14 
      genotypes and IgE as well as atopic outcomes in this large German study 
      population seems to indicate that CD14 genotypes may not directly be involved in 
      the development of allergies during childhood.
FAU - Kabesch, M
AU  - Kabesch M
AD  - University Children's Hospital, Ludwig Maximilian's University Munich, Munchen, 
      Germany.
FAU - Hasemann, K
AU  - Hasemann K
FAU - Schickinger, V
AU  - Schickinger V
FAU - Tzotcheva, I
AU  - Tzotcheva I
FAU - Bohnert, A
AU  - Bohnert A
FAU - Carr, D
AU  - Carr D
FAU - Baldini, M
AU  - Baldini M
FAU - Hackstein, H
AU  - Hackstein H
FAU - Leupold, W
AU  - Leupold W
FAU - Weiland, S K
AU  - Weiland SK
FAU - Martinez, F D
AU  - Martinez FD
FAU - Mutius, E
AU  - Mutius E
FAU - Bein, G
AU  - Bein G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8J337D1HZY (Cytosine)
RN  - QR26YLT7LT (Thymine)
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cytosine
MH  - Female
MH  - Genotype
MH  - Germany/epidemiology
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Immunoglobulin E/*blood
MH  - Lipopolysaccharide Receptors/*blood/chemistry/*genetics
MH  - Male
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - *Promoter Regions, Genetic
MH  - Solubility
MH  - Thymine
EDAT- 2004/04/15 05:00
MHDA- 2004/08/10 05:00
CRDT- 2004/04/15 05:00
PHST- 2004/04/15 05:00 [pubmed]
PHST- 2004/08/10 05:00 [medline]
PHST- 2004/04/15 05:00 [entrez]
AID - ALL439 [pii]
AID - 10.1111/j.1398-9995.2004.00439.x [doi]
PST - ppublish
SO  - Allergy. 2004 May;59(5):520-5. doi: 10.1111/j.1398-9995.2004.00439.x.