PMID- 15081172
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20171116
IS  - 0304-3894 (Print)
IS  - 0304-3894 (Linking)
VI  - 108
IP  - 1-2
DP  - 2004 Apr 30
TI  - Solubilization of the neutral and charged forms of 2,4,6-trichlorophenol by 
      hydroxypropyl-beta-cyclodextrin, or methyl-beta-cyclodextrin in water.
PG  - 129-31
AB  - The solubility of 2,4,6-trichlorophenol (TCP) in hydroxypropyl-beta-cyclodextrin 
      (HPbetaCD), or methyl-beta-cyclodextrin (MebetaCD) at pH 3.0 and 8.8 reported by 
      Hanna et al. [J. Hazard. Mater. B100 (2003) 109] is reevaluated in this paper. 
      The complexations of the individual dissolved forms were examined. As expected, 
      the neutral TCP complexes more strongly with the cyclodextrins than the charged 
      species. However, in spite of its lower complexation constant, the charged form 
      of TCP forms more complex with each CD, and thus is solubilized to a greater 
      extent.
FAU - He, Yan
AU  - He Y
AD  - College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA. 
      he@pharmacy.arizona.edu
FAU - Yalkowsky, Samuel H
AU  - Yalkowsky SH
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Chlorophenols)
RN  - 0 (Cyclodextrins)
RN  - 0 (Excipients)
RN  - 0 (Mutagens)
RN  - 0 (beta-Cyclodextrins)
RN  - 0 (methyl-beta-cyclodextrin)
RN  - 059QF0KO0R (Water)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
RN  - MHS8C5BAUZ (2,4,6-trichlorophenol)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin
MH  - Chlorophenols/*chemistry
MH  - Cyclodextrins/chemistry
MH  - Excipients/chemistry
MH  - Mutagens/*chemistry
MH  - Solubility
MH  - Water
MH  - *beta-Cyclodextrins
EDAT- 2004/04/15 05:00
MHDA- 2004/07/21 05:00
CRDT- 2004/04/15 05:00
PHST- 2003/07/31 00:00 [received]
PHST- 2003/10/22 00:00 [revised]
PHST- 2003/12/06 00:00 [accepted]
PHST- 2004/04/15 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2004/04/15 05:00 [entrez]
AID - S0304389404000378 [pii]
AID - 10.1016/j.jhazmat.2003.12.008 [doi]
PST - ppublish
SO  - J Hazard Mater. 2004 Apr 30;108(1-2):129-31. doi: 10.1016/j.jhazmat.2003.12.008.