PMID- 15082170
OWN - NLM
STAT- MEDLINE
DCOM- 20040604
LR  - 20061115
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 360
IP  - 1-2
DP  - 2004 Apr 22
TI  - No evidence for association of the monocyte chemoattractant protein-1 (-2518) 
      gene polymorphism and Alzheimer's disease.
PG  - 25-8
AB  - Activation of microglia is a central part of the chronic inflammatory process in 
      Alzheimer disease (AD). The monocyte chemoattractant protein-1 (MCP-1) is a 
      chemokine that plays a role in microglial migration and accumulation at sites of 
      beta-amyloid deposition in senile plaques in the AD brain. A polymorphism in the 
      regulatory region (-2518) of the MCP-1 gene affects the level of MCP-1 
      expression, and has been associated with a stronger inflammatory response and 
      higher peripheral tissue damage in chronic inflammatory diseases. We investigated 
      whether the MCP-1 (-2518) polymorphism might be responsible for susceptibility to 
      AD in a large Spanish population, utilizing a clinically well-defined group of 
      328 sporadic AD patients and 315 control subjects. We also examined the combined 
      gene effects between MCP-1 and other proinflammatory cytokine genes such as 
      interleukin-1A (IL-1A) and tumor necrosis factor-alpha (TNF-alpha), and the 
      apolipoprotein E (APOE) gene. In the present study, neither the MCP-1 (-2518) G 
      allele itself nor its interaction with the IL-1A (-889) allele 2, TNF-alpha 
      (-850) allele T or APOE epsilon4 allele conferred increased risk for AD.
FAU - Combarros, Onofre
AU  - Combarros O
AD  - Service of Neurology, University Hospital Marques de Valdecilla, University of 
      Cantabria, 39008 Santander, Spain. combarro@unican.es
FAU - Infante, Jon
AU  - Infante J
FAU - Llorca, Javier
AU  - Llorca J
FAU - Berciano, Jose
AU  - Berciano J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Confidence Intervals
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
EDAT- 2004/04/15 05:00
MHDA- 2004/06/05 05:00
CRDT- 2004/04/15 05:00
PHST- 2003/11/10 00:00 [received]
PHST- 2004/01/16 00:00 [accepted]
PHST- 2004/04/15 05:00 [pubmed]
PHST- 2004/06/05 05:00 [medline]
PHST- 2004/04/15 05:00 [entrez]
AID - S0304394004000977 [pii]
AID - 10.1016/j.neulet.2004.01.035 [doi]
PST - ppublish
SO  - Neurosci Lett. 2004 Apr 22;360(1-2):25-8. doi: 10.1016/j.neulet.2004.01.035.