PMID- 15083265
OWN - NLM
STAT- MEDLINE
DCOM- 20041122
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 173
IP  - 3-4
DP  - 2004 May
TI  - Effects of a single dose of 3,4-methylenedioxymethamphetamine on circadian 
      patterns, motor activity and sleep in drug-naive rats and rats previously exposed 
      to MDMA.
PG  - 296-309
AB  - RATIONALE: Despite the well documented neurochemical actions of 
      3,4-methylenedioxymethamphetamine (MDMA), acute effects in rats previously 
      exposed to the drug have not been extensively explored. OBJECTIVE: To examine 
      motor activity and vigilance effects of MDMA in drug-naive rats and in rats 
      exposed to the drug 3 weeks earlier. METHODS: MDMA (15 mg/kg, i.p.) was 
      administered to Dark Agouti rats. Motor activity, wakefulness, light slow wave 
      sleep (SWS-1), deep slow wave sleep (SWS-2) and paradoxical sleep (PS), sleep and 
      PS latencies were measured. Acrophases and amplitudes of the 24 h cycles were 
      calculated by cosinor analysis. In parallel groups, local cerebral glucose 
      utilization (lCMRglu) and (3H)-paroxetine binding were measured in motor areas of 
      the brain. RESULTS: In drug-naive rats MDMA caused marked increases in motor 
      activity and wakefulness for at least 5-6 h. Circadian patterns of motor activity 
      and sleep/vigilance parameters were altered up to 5 days after treatment. Despite 
      most parameters tending to return to normal, there were still significant effects 
      of MDMA on motor activity, wakefulness, and SWS-2 28 days later. Acute MDMA 
      administration caused significant increases in lCMRglu, but after 3 weeks lCMRglu 
      was decreased in the same brain areas. No significant change in [3H]paroxetine 
      binding was observed in motor areas, although significant reductions were seen 
      elsewhere (neocortex -81%). In rats exposed to MDMA 3 weeks earlier, most acute 
      effects induced by MDMA administration were similar to those in drug-naive rats, 
      but shorter duration of the acute effects were found in motor activity and 
      vigilance. CONCLUSIONS: Our findings provide evidence that MDMA use can lead to 
      long-term changes in regulation of circadian rhythms, motor activity and sleep 
      generation.
FAU - Balogh, Brigitta
AU  - Balogh B
AD  - Laboratory of Neurochemistry and Experimental Medicine and Department of Vascular 
      Neurology, Semmelweis University, National Institute of Psychiatry and Neurology, 
      Huvosvolgyi ut 116, 1021 Budapest, Hungary.
FAU - Molnar, Eszter
AU  - Molnar E
FAU - Jakus, Rita
AU  - Jakus R
FAU - Quate, Linda
AU  - Quate L
FAU - Olverman, Henry J
AU  - Olverman HJ
FAU - Kelly, Paul A T
AU  - Kelly PA
FAU - Kantor, Sandor
AU  - Kantor S
FAU - Bagdy, Gyorgy
AU  - Bagdy G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040409
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - IY9XDZ35W2 (Glucose)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Brain/drug effects/metabolism
MH  - Circadian Rhythm/*drug effects
MH  - Glucose/metabolism
MH  - Male
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Radioligand Assay
MH  - Rats
MH  - Sleep/*drug effects
MH  - Wakefulness/drug effects
EDAT- 2004/04/15 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/04/15 05:00
PHST- 2003/09/30 00:00 [received]
PHST- 2003/12/21 00:00 [accepted]
PHST- 2004/04/15 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/04/15 05:00 [entrez]
AID - 10.1007/s00213-004-1787-9 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2004 May;173(3-4):296-309. doi: 
      10.1007/s00213-004-1787-9. Epub 2004 Apr 9.