PMID- 15083289
OWN - NLM
STAT- MEDLINE
DCOM- 20050301
LR  - 20111117
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 251
IP  - 4
DP  - 2004 Apr
TI  - DQB1*0602 allele shows a strong association with multiple sclerosis in patients 
      in Malaga, Spain.
PG  - 440-4
AB  - BACKGROUND: The human leukocyte antigen (HLA) class II DR2 haplotype (DRB1*1501, 
      DQA1*0102, DQB1*0602) has been associated with multiple sclerosis (MS) in all 
      ethnic groups and very strongly in Caucasians. AIM: To investigate the possible 
      HLA class II (DRB1, DQA1 and DQB1) associations with MS in Malaga, southern 
      Spain. METHODS: We analysed the HLA class II sub-regions DRB1, DQA1 and DQB1 by 
      polymerase chain reaction (PCR) and sequence-specific oligonucleotide probe 
      hybridization (PCR/SSO) for DRB1 and DQB1 and with sequence-specific primers 
      (PCR/SSP) for DRB1 subtypes and DQA1. Possible HLA class II associations with 
      clinical MS characteristics were investigated in 149 subjects with and 160 
      without MS. RESULTS: Associations were detected between MS and the HLA class II 
      alleles DRB1*1501 (45.6 % vs. 21.3%, p=0.001), DQA1*0102 (44% vs. 29.4%, p=0.001) 
      and DQB1*0602 (45% vs. 20.6%, p=0.001). The DR2 haplotype (DRB1*1501, DQA1*0102, 
      DQB1*0602) was associated with MS (43.6 % vs. 20%, p=0.002). DQB1*0602 was the 
      only allele that maintained an association with MS in a logistic regression 
      model. No HLA class II alleles or genotypes were significantly associated with 
      any clinical characteristics of MS. CONCLUSIONS: Our results confirm the positive 
      association of the DR2 haplotype with MS, particularly the allele DQB1*0602, in 
      the population studied. DR4 was not associated with the disease in Malaga. HLA 
      class II alleles or haplotypes were not associated with clinical or demographic 
      characteristics, or clinical form or severity of MS.
FAU - Fernandez, O
AU  - Fernandez O
AD  - Dept. of Neurology, Hospital Regional Universitario Carlos Haya, Avda. Carlos 
      Haya s/n, 29010 Malaga, Spain. oscar.fernandez.sspa.@juntadeandalucia.es
FAU - Fernandez, V
AU  - Fernandez V
FAU - Alonso, A
AU  - Alonso A
FAU - Caballero, A
AU  - Caballero A
FAU - Luque, G
AU  - Luque G
FAU - Bravo, M
AU  - Bravo M
FAU - Leon, A
AU  - Leon A
FAU - Mayorga, C
AU  - Mayorga C
FAU - Leyva, L
AU  - Leyva L
FAU - de Ramon, E
AU  - de Ramon E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Child
MH  - Cohort Studies
MH  - Confidence Intervals
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*genetics
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Phenotype
MH  - Spain
EDAT- 2004/04/15 05:00
MHDA- 2005/03/02 09:00
CRDT- 2004/04/15 05:00
PHST- 2002/10/25 00:00 [received]
PHST- 2003/11/03 00:00 [revised]
PHST- 2003/11/17 00:00 [accepted]
PHST- 2004/04/15 05:00 [pubmed]
PHST- 2005/03/02 09:00 [medline]
PHST- 2004/04/15 05:00 [entrez]
AID - 10.1007/s00415-004-0350-2 [doi]
PST - ppublish
SO  - J Neurol. 2004 Apr;251(4):440-4. doi: 10.1007/s00415-004-0350-2.