PMID- 15084795
OWN - NLM
STAT- MEDLINE
DCOM- 20040728
LR  - 20080324
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 18
IP  - 1
DP  - 2004
TI  - Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not 
      associated with sporadic Alzheimer's disease.
PG  - 55-8
AB  - Memory acquisition and consolidation are associated with an increase in 
      brain-derived neurotrophic factor (BDNF) in synapses, particularly those 
      innervating the hippocampus and cerebral cortex. A polymorphism producing an 
      amino acid substitution (valine to methionine) at codon 66 of the BDNF gene could 
      affect intracellular processing and secretion of BDNF and lead to impairments in 
      hippocampal function. Preliminary evidence in an Italian population indicates 
      that this polymorphism is a predisposing factor for sporadic Alzheimer's disease 
      (AD). A case-control study utilizing a clinically well-defined group of 237 
      sporadic AD patients and 218 control subjects was performed to test this 
      association. The current study does not demonstrate any significant difference in 
      Val66Met BDNF genotype or allele frequencies between AD patients and controls. 
      Our study in the Spanish population argues against the hypothesis that this 
      polymorphism is causally related to AD.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Combarros, Onofre
AU  - Combarros O
AD  - Neurology Service, University Hospital 'Marques de Valdecilla', University of 
      Cantabria, Santander, Spain. combarro@unican.es
FAU - Infante, Jon
AU  - Infante J
FAU - Llorca, Javier
AU  - Llorca J
FAU - Berciano, Jose
AU  - Berciano J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040406
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Codon)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/epidemiology/*genetics
MH  - Apolipoprotein E4
MH  - Apolipoproteins E/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Codon/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Risk
MH  - Spain/epidemiology
EDAT- 2004/04/16 05:00
MHDA- 2004/07/29 05:00
CRDT- 2004/04/16 05:00
PHST- 2003/10/11 00:00 [accepted]
PHST- 2004/04/16 05:00 [pubmed]
PHST- 2004/07/29 05:00 [medline]
PHST- 2004/04/16 05:00 [entrez]
AID - 77736 [pii]
AID - 10.1159/000077736 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2004;18(1):55-8. doi: 10.1159/000077736. Epub 2004 
      Apr 6.