PMID- 15086616
OWN - NLM
STAT- MEDLINE
DCOM- 20040603
LR  - 20220311
IS  - 0303-6979 (Print)
IS  - 0303-6979 (Linking)
VI  - 31
IP  - 5
DP  - 2004 May
TI  - A comparative study on the use of a HA/collagen/chondroitin sulphate biomaterial 
      (Biostite) and a bovine-derived HA xenograft (Bio-Oss) in the treatment of deep 
      intra-osseous defects.
PG  - 348-55
AB  - OBJECTIVES: This parallel-group, randomized, clinical trial was designed to 
      evaluate the clinical outcome of deep intra-osseous defects following 
      reconstructive surgery with the use of a synthetic hydroxyapatite/equine Type I 
      collagen/chondroitin sulphate biomaterial (Biostite), as compared to a 
      bovine-derived hydroxyapatite xenograft (Bio-Oss). MATERIAL AND METHODS: 
      Twenty-four systemically healthy subjects with moderate to advanced 
      periodontitis, 11 females and 13 males, aged 30-64 years, seven smokers, were 
      selected. Patients presented with one interproximal deep intra-osseous defect 
      (intra-osseous component >or=4 mm) as clinically and radiographically evaluated. 
      Immediately before surgery and 12 months after surgery, pocket probing depth 
      (PPD), clinical attachment level (CAL) and radiographic depth of the defect 
      (DEPTH) were evaluated. RESULTS: Thirteen defects were treated with Biostite 
      (test) and 11 defects with Bio-Oss (control). In the test group, PPD amounted to 
      7.8+/-1.3 mm before surgery, and decreased significantly to 3.6+/-1.6 mm 12 
      months following surgery, while in the control group PPD significantly decreased 
      from 7.5+/-2.0 mm pre-surgery to 3.1+/-1.0 mm post-surgery. At 1 year, CAL gain 
      and DEPTH gain were 2.9+/-1.9 and 2.5+/-1.4 mm, respectively, in the test group, 
      and 4.0+/-2.4 mm and 3.1+/-1.8 mm, respectively, in the control group. No 
      statistically significant differences for PPD reduction, CAL gain and DEPTH gain 
      were detected between the groups. CONCLUSIONS: The results of the present study 
      indicate that both Biostite and Bio-Oss grafting biomaterials have determined a 
      clinically and statistically significant improvement in terms of CAL gain, PPD 
      reduction and radiographic DEPTH gain when used for the treatment of deep 
      intra-osseous defects.
FAU - Scabbia, Alessandro
AU  - Scabbia A
AD  - Research Center for the Study of Periodontal Diseases, University of Ferrara, 
      Ferrara, Italy.
FAU - Trombelli, Leonardo
AU  - Trombelli L
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Bio-Oss)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Biostite)
RN  - 0 (Bone Substitutes)
RN  - 0 (Glycosaminoglycans)
RN  - 0 (Hydroxyapatites)
RN  - 0 (Minerals)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Alveolar Bone Loss/diagnostic imaging/*surgery
MH  - Alveolar Process/diagnostic imaging
MH  - Animals
MH  - Biocompatible Materials/*therapeutic use
MH  - Bone Matrix/*transplantation
MH  - Bone Substitutes/*therapeutic use
MH  - Cattle
MH  - Chi-Square Distribution
MH  - Collagen/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Glycosaminoglycans/*therapeutic use
MH  - Humans
MH  - Hydroxyapatites/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Minerals/*therapeutic use
MH  - Periodontal Attachment Loss/surgery
MH  - Periodontal Pocket/surgery
MH  - Periodontitis/surgery
MH  - Radiography
MH  - Transplantation, Heterologous
MH  - Treatment Outcome
EDAT- 2004/04/17 05:00
MHDA- 2004/06/04 05:00
CRDT- 2004/04/17 05:00
PHST- 2004/04/17 05:00 [pubmed]
PHST- 2004/06/04 05:00 [medline]
PHST- 2004/04/17 05:00 [entrez]
AID - CPE483 [pii]
AID - 10.1111/j.1600-051X.2004.00483.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2004 May;31(5):348-55. doi: 10.1111/j.1600-051X.2004.00483.x.