PMID- 15087778
OWN - NLM
STAT- MEDLINE
DCOM- 20040506
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 77
IP  - 7
DP  - 2004 Apr 15
TI  - Eosinophilia correlates with the presence or development of chronic 
      graft-versus-host disease in children.
PG  - 1096-100
AB  - Finding predictors of chronic graft-versus-host disease (cGVHD) in children would 
      be extremely useful. Because of recent data suggesting that cGVHD may be a 
      Th-2-mediated process, a theoretical foundation linking eosinophilia and cGVHD 
      exists. While an association between eosinophilia and cGVHD has been described in 
      adults, it has never been described in children. We studied 53 patients that 
      received allogeneic hematopoietic stem cell transplants (SCT) between 1999 and 
      2002. Ten (19%) of these patients developed eosinophilia (absolute eosinophil 
      count (AEC) > 500x 10/L) after day 100. Of these ten, eight either had or later 
      developed cGVHD. We conclude that following the peripheral eosinophil count in 
      children post-SCT is useful, and a rise in the AEC may herald the development of 
      cGVHD. Taking the AEC into account with other risk factors (such as previous 
      grade II-IV acute GVHD, human leukocyte antigen (HLA)-mismatch, and unrelated 
      donor (URD) transplant) may improve our ability to predict cGVHD.
FAU - Jacobsohn, David A
AU  - Jacobsohn DA
AD  - Department of Pediatrics, Children's Memorial Hospital, Chicago, IL 60614, USA. 
      djacobsohn@childrensmemorial.org
FAU - Schechter, Tali
AU  - Schechter T
FAU - Seshadri, Roopa
AU  - Seshadri R
FAU - Thormann, Kimberly
AU  - Thormann K
FAU - Duerst, Reggie
AU  - Duerst R
FAU - Kletzel, Morris
AU  - Kletzel M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Eosinophilia/*etiology
MH  - Graft vs Host Disease/*etiology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Retrospective Studies
MH  - Transplantation, Homologous
EDAT- 2004/04/17 05:00
MHDA- 2004/05/07 05:00
CRDT- 2004/04/17 05:00
PHST- 2004/04/17 05:00 [pubmed]
PHST- 2004/05/07 05:00 [medline]
PHST- 2004/04/17 05:00 [entrez]
AID - 00007890-200404150-00025 [pii]
AID - 10.1097/01.tp.0000118409.92769.fa [doi]
PST - ppublish
SO  - Transplantation. 2004 Apr 15;77(7):1096-100. doi: 
      10.1097/01.tp.0000118409.92769.fa.