PMID- 15087781
OWN - NLM
STAT- MEDLINE
DCOM- 20040506
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 77
IP  - 7
DP  - 2004 Apr 15
TI  - Hla-DPB1 mismatch in HLA-A-B-DRB1 identical sibling donor stem cell 
      transplantation and acute graft-versus-host disease.
PG  - 1107-10
AB  - BACKGROUND: The role of human leukocyte antigen (HLA)-DPB1 as a transplantation 
      antigen is controversial. A higher incidence of acute graft-versus-host disease 
      (aGVHD) has been described after unrelated donor bone marrow transplant when both 
      HLA-DPB1 alleles were mismatched. METHODS: We investigated the impact of a single 
      HLA-DPB1 mismatch after HLA-A-B-DRB1 identical sibling donor transplantation on 
      aGVHD. We analyzed 627 adult patient-donor pairs and identified 30 pairs without 
      HLA-DPB1 identity (4.78%). In 17 cases, the patient had an allele that was not 
      shared by the donor. RESULTS: The cumulative incidence of grades II-IV aGVHD was 
      higher in the HLA-DPB1 mismatched group (66.7% vs. 35.7%, p=0.012). The HLA-DPB1 
      mismatch was identified by multivariate analysis as an independent risk factor 
      for aGVHD (p=0.020, RR=2.68, 95% CI: 1.73-3.62). CONCLUSIONS: HLA-DPB1 can 
      mediate alloreactive responses. A single HLA-DPB1 mismatch increases the risk of 
      aGVHD after sibling donor stem cell transplantation.
FAU - Gallardo, David
AU  - Gallardo D
AD  - Alloreactivity Unit of the Institut Catala d'Oncologia, Barcelona, Spain. 
      27532dgg@comb.es
FAU - Brunet, Salut
AU  - Brunet S
FAU - Torres, Antonio
AU  - Torres A
FAU - Alonso-Nieto, Manuela
AU  - Alonso-Nieto M
FAU - Vallejo, Carlos
AU  - Vallejo C
FAU - Jimenez, Antonio
AU  - Jimenez A
FAU - Gonzalez, Marcos
AU  - Gonzalez M
FAU - Sanz, Guillermo
AU  - Sanz G
FAU - Serrano, David
AU  - Serrano D
FAU - Espigado, Ildefonso
AU  - Espigado I
FAU - Osorio, Santiago
AU  - Osorio S
FAU - Carreras, Enric
AU  - Carreras E
FAU - Martiin, Carmen
AU  - Martiin C
FAU - Sanz-Rodriguez, Cesar
AU  - Sanz-Rodriguez C
FAU - Sierra, Jorge
AU  - Sierra J
FAU - Zuazu, Javier
AU  - Zuazu J
FAU - Gonzalez-Escribano, M Francisca
AU  - Gonzalez-Escribano MF
FAU - Gonzalez, Juan R
AU  - Gonzalez JR
FAU - Roman, Jose
AU  - Roman J
FAU - De Oteyza, Jaime Perez
AU  - De Oteyza JP
FAU - De La Camara, Rafael
AU  - De La Camara R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Graft vs Host Disease/*etiology
MH  - HLA-A Antigens/*immunology
MH  - HLA-B Antigens/*immunology
MH  - HLA-DP Antigens/*immunology
MH  - HLA-DP beta-Chains
MH  - HLA-DR Antigens/*immunology
MH  - HLA-DRB1 Chains
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Stem Cell Transplantation/*adverse effects
MH  - Tissue Donors
EDAT- 2004/04/17 05:00
MHDA- 2004/05/07 05:00
CRDT- 2004/04/17 05:00
PHST- 2004/04/17 05:00 [pubmed]
PHST- 2004/05/07 05:00 [medline]
PHST- 2004/04/17 05:00 [entrez]
AID - 00007890-200404150-00028 [pii]
AID - 10.1097/01.tp.0000122225.10296.10 [doi]
PST - ppublish
SO  - Transplantation. 2004 Apr 15;77(7):1107-10. doi: 
      10.1097/01.tp.0000122225.10296.10.