PMID- 15088316
OWN - NLM
STAT- MEDLINE
DCOM- 20040603
LR  - 20220316
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 31
IP  - 4
DP  - 2004 Apr
TI  - Docetaxel (taxotere) induced subacute cutaneous lupus erythematosus: report of 4 
      cases.
PG  - 818-20
AB  - OBJECTIVE: We describe 4 patients who developed subacute cutaneous lupus 
      erythematosus (SCLE)-like photodistributed eruptions after ingestion of docetaxel 
      (Taxotere). The development of SCLE-like cutaneous eruptions has been associated 
      with the intake of drugs including thiazide diuretics, calcium channel blockers, 
      angiotensin converting-enzyme inhibitors, phenytoin, etanercept, antihistaminics, 
      interferons, statins, and terbinafine. Docetaxel, a chemotherapeutic drug used in 
      breast cancer therapy, has not to our knowledge been reported to cause SCLE. 
      METHODS: Skin biopsies were obtained from 4 patients with photodistributed rashes 
      while taking docetaxel. RESULTS: In all patients, skin biopsies were remarkable 
      for an atrophying interface dermatitis associated with mucin deposition. 
      Immunofluorescent testing revealed the characteristic pattern of SCLE, namely, 
      granular epidermal keratinocyte deposition of IgG and C5b-9. The eruptions 
      resolved following cessation of the drug. CONCLUSION: Pathogenetically, docetaxel 
      may evoke a lupus-like eruption through its proapoptotic effects on replicating 
      cells, which could in turn provoke the release of nucleosomes postulated to be 
      target antigens in LE. It seems reasonable to postulate that the rapidly 
      replicating keratinocyte, when subjected to the cytotoxic effects of docetaxel, 
      would also manifest nucleosome release followed by a local autoimmune reaction in 
      a genetically predisposed host.
FAU - Chen, Michael
AU  - Chen M
AD  - Ohio State University College of Medicine, Columbus, Ohio 43210, USA.
FAU - Crowson, A Neil
AU  - Crowson AN
FAU - Woofter, Melinda
AU  - Woofter M
FAU - Luca, Mary Beth
AU  - Luca MB
FAU - Magro, Cynthia M
AU  - Magro CM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Biomarkers)
RN  - 0 (Complement Membrane Attack Complex)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Mucins)
RN  - 0 (Taxoids)
RN  - 15H5577CQD (Docetaxel)
SB  - IM
MH  - Aged
MH  - Antineoplastic Agents, Phytogenic/*adverse effects
MH  - Biomarkers/analysis
MH  - Complement Membrane Attack Complex/metabolism
MH  - Dermatitis/etiology/metabolism/pathology
MH  - Docetaxel
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/metabolism
MH  - Immunohistochemistry
MH  - Keratinocytes/drug effects/metabolism/pathology
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/pathology
MH  - Middle Aged
MH  - Mucins/metabolism
MH  - Recovery of Function
MH  - Remission Induction
MH  - Skin/drug effects/metabolism/pathology
MH  - Taxoids/*adverse effects
EDAT- 2004/04/17 05:00
MHDA- 2004/06/04 05:00
CRDT- 2004/04/17 05:00
PHST- 2004/04/17 05:00 [pubmed]
PHST- 2004/06/04 05:00 [medline]
PHST- 2004/04/17 05:00 [entrez]
AID - 0315162X-31-818 [pii]
PST - ppublish
SO  - J Rheumatol. 2004 Apr;31(4):818-20.