PMID- 15089783
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20161124
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 21
IP  - 5
DP  - 2004 May
TI  - Prevention of Type 2 diabetes mellitus. A review of the evidence and its 
      application in a UK setting.
PG  - 403-14
AB  - Abstract Type 2 Diabetes mellitus (T2DM) is a complex metabolic, multifactorial 
      disease, which affects the quality, quantity and style of life. People with T2DM 
      have a life expectancy that can be shortened by as much as 15 years, with up to 
      75% dying of macrovascular complications. To reduce the impact of T2DM in the 
      21st century, we need an approach that not only optimally treats the person with 
      established diabetes but also prevents diabetes from occurring in the first 
      place. The best evidence for prevention of diabetes is for interventions that 
      target individuals at highest risk. Targeting patients who have impaired glucose 
      tolerance with lifestyle changes including physical activity and dietary factors 
      has been shown to be effective in the Chinese, North American and Finnish 
      populations. In order for such lifestyle interventions to be successful in other 
      populations, they need to be culturally sensitive, individualized and sustained. 
      Some pharmacological agents including metformin and acarbose have also been shown 
      to be effective, although the profile of those who respond is different. There 
      continues to be a need to develop and evaluate interventions that target 
      communities and populations at risk in a UK setting.
FAU - Davies, M J
AU  - Davies MJ
AD  - Department of Diabetes, University Hospitals of Leicester NHS Trust, Leicester 
      Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK. 
      melanie.davies@uhl-tr.nhs.uk
FAU - Tringham, J R
AU  - Tringham JR
FAU - Troughton, J
AU  - Troughton J
FAU - Khunti, K K
AU  - Khunti KK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Hypoglycemic Agents)
SB  - IM
CIN - Diabet Med. 2005 Sep;22(9):1285-6; author reply 1286-7. doi: 
      10.1111/j.1464-5491.2005.1515a.x. PMID: 16108865
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - Glucose Intolerance/therapy
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Life Style
MH  - Mass Screening/methods
MH  - Risk Factors
MH  - United Kingdom
RF  - 106
EDAT- 2004/04/20 05:00
MHDA- 2004/07/21 05:00
CRDT- 2004/04/20 05:00
PHST- 2004/04/20 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2004/04/20 05:00 [entrez]
AID - DME1176 [pii]
AID - 10.1111/j.1464-5491.2004.01176.x [doi]
PST - ppublish
SO  - Diabet Med. 2004 May;21(5):403-14. doi: 10.1111/j.1464-5491.2004.01176.x.