PMID- 15089978
OWN - NLM
STAT- MEDLINE
DCOM- 20040609
LR  - 20061115
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 16
IP  - 4
DP  - 2004 Apr
TI  - Novel G-protein coupled receptor ligands and neurohypophysial hormones.
PG  - 378-82
AB  - Recently, novel peptides have been identified as unknown ligands of orphan 
      G-protein coupled receptors. In the paraventicular (PVN) and supraoptic nuclei 
      (SON), the expression of the G-protein genes are abundant. In this review, we 
      focus on the physiological role of neuromedin U and galanin-like peptide, which 
      were recently identified as ligands of G-protein coupled receptors, in the 
      regulation of neurohypophysial hormones. Intracerebroventricular (i.c.v) 
      administration of neuromedin U induced the expression of c-fos mRNA in both the 
      magnocellular and parvocellular division of the PVN and throughout the SON. 
      Administration of i.c.v. neuromedin U caused a significant increase in plasma 
      concentrations of vasopressin and oxytocin as well as adrenocorticotropic 
      hormone. The expression of galanin-like peptide mRNA was observed in the 
      pituicytes of rat posterior pituitary gland. The expression of galanin-like 
      peptide mRNA in the posterior pituitary gland was markedly increased after 
      dehydration, salt loading and intraperitoneal administration of 
      lipopolysaccaride, challenges that stimulate the secretion of vasopressin and 
      oxytocin, and which activate the hypothalamic-pituitary adrenal axis. These 
      results suggest that neuromedin U and galanin-like peptide may have an important 
      role in the regulation of both the hypothalamic-neurohypophysial system and the 
      hypothalamic-adrenohypophysial system.
FAU - Ueta, Y
AU  - Ueta Y
AD  - Department of Physiology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan. yoichi@med.uoeh-u.ac.jp
FAU - Ozaki, Y
AU  - Ozaki Y
FAU - Saito, J
AU  - Saito J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Ligands)
RN  - 0 (Pituitary Hormones)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - Ligands
MH  - Pituitary Gland/*metabolism
MH  - Pituitary Hormones/*metabolism
MH  - Receptors, G-Protein-Coupled/*metabolism
RF  - 50
EDAT- 2004/04/20 05:00
MHDA- 2004/06/21 10:00
CRDT- 2004/04/20 05:00
PHST- 2004/04/20 05:00 [pubmed]
PHST- 2004/06/21 10:00 [medline]
PHST- 2004/04/20 05:00 [entrez]
AID - JNE1179 [pii]
AID - 10.1111/j.0953-8194.2004.01179.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2004 Apr;16(4):378-82. doi: 10.1111/j.0953-8194.2004.01179.x.