PMID- 15090459
OWN - NLM
STAT- MEDLINE
DCOM- 20040830
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 104
IP  - 3
DP  - 2004 Aug 1
TI  - Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a 
      high frequency of aberrations and allows a refined characterization of consensus 
      regions.
PG  - 795-801
AB  - Tumor samples of 53 patients with t(11;14)-positive mantle cell lymphomas (MCLs) 
      were analyzed by matrix-based comparative genomic hybridization (matrix-CGH) 
      using a dedicated DNA array. In 49 cases, genomic aberrations were identified. In 
      comparison to chromosomal CGH, a 50% higher number of aberrations was found and 
      the high specificity of matrix-CGH was demonstrated by fluorescence in situ 
      hybridization (FISH) analyses. The 11q gains and 13q34 deletions, which have not 
      been described as frequent genomic aberrations in MCL, were identified by 
      matrix-CGH in 15 and 26 cases, respectively. For several genomic aberrations, 
      novel consensus regions were defined: 8p21 (size of the consensus region, 2.4 
      megabase pairs [Mbp]; candidate genes: TNFRSF10B, TNFRSF10C, TNFRSF10D); 10p13 
      (2.7 Mbp; BMI1); 11q13 (1.4 Mbp; RELA); 11q13 (5.2 Mbp; CCND1); 13q14 (0.4 Mbp; 
      RFP2, BCMSUN) and 13q34 (6.9 Mbp). In univariate analyses correlating genomic 
      aberrations and clinical course, 8p- and 13q14- deletions were associated with an 
      inferior overall survival. These data provide a basis for further studies 
      focusing on the identification of pathogenetically or clinically relevant genes 
      in MCL.
FAU - Kohlhammer, Holger
AU  - Kohlhammer H
AD  - Department of Innere Medizin I, Medizinische Klinik der Universitat Ulm, Ulm, 
      Germany.
FAU - Schwaenen, Carsten
AU  - Schwaenen C
FAU - Wessendorf, Swen
AU  - Wessendorf S
FAU - Holzmann, Karlheinz
AU  - Holzmann K
FAU - Kestler, Hans A
AU  - Kestler HA
FAU - Kienle, Dirk
AU  - Kienle D
FAU - Barth, Thomas F E
AU  - Barth TF
FAU - Moller, Peter
AU  - Moller P
FAU - Ott, German
AU  - Ott G
FAU - Kalla, Jorg
AU  - Kalla J
FAU - Radlwimmer, Bernhard
AU  - Radlwimmer B
FAU - Pscherer, Armin
AU  - Pscherer A
FAU - Stilgenbauer, Stephan
AU  - Stilgenbauer S
FAU - Dohner, Hartmut
AU  - Dohner H
FAU - Lichter, Peter
AU  - Lichter P
FAU - Bentz, Martin
AU  - Bentz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040413
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Consensus Sequence
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Mantle-Cell/*genetics/pathology
MH  - Neoplasm Staging
MH  - Nucleic Acid Hybridization/*methods
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Retrospective Studies
MH  - *Translocation, Genetic
EDAT- 2004/04/20 05:00
MHDA- 2004/08/31 05:00
CRDT- 2004/04/20 05:00
PHST- 2004/04/20 05:00 [pubmed]
PHST- 2004/08/31 05:00 [medline]
PHST- 2004/04/20 05:00 [entrez]
AID - S0006-4971(20)43610-9 [pii]
AID - 10.1182/blood-2003-12-4175 [doi]
PST - ppublish
SO  - Blood. 2004 Aug 1;104(3):795-801. doi: 10.1182/blood-2003-12-4175. Epub 2004 Apr 
      13.