PMID- 15090705
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20190827
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 45
IP  - 2
DP  - 2004 Mar
TI  - Regulation of the catecholamine beta-adrenergic system in ventricular remodeling 
      of hypertension.
PG  - 285-96
AB  - Differences in structural remodeling are believed to be influenced by hormonal 
      systems in hypertension. The objective of the present study was to investigate 
      the change in the circulating catecholamine beta-adrenergic system in the left 
      ventricle remodeling process in hypertensives. One hundred and thirty-four men 
      (mean age, 53 years) had essential hypertension and underwent echocardiography 
      before treatment. Normal morphology (n = 26) and concentric remodeling (n = 41) 
      were defined by a relative wall thickness at diastole (RWT) of < 0.44 and > or = 
      0.44, respectively, and concentric hypertrophy (n = 28) and eccentric hypertrophy 
      (n = 39) by a left ventricular mass index (LVMI) of < 150 g/m(2) and > or = 150 
      g/m(2), respectively. Forty healthy males were studied as normal controls. Plasma 
      levels of norepinephrine (NE) and epinephrine (E) were measured by high 
      performance liquid chromatography. The density of lymphocyte beta-adrenoceptors 
      (beta-AR) and the content of intralymphocyte cyclic AMP (cAMP) in peripheral 
      blood were measured using (3)H-dihydroalpneol as a ligand and protein binding 
      assay, respectively. The plasma levels of NE and E in the 4 groups of patients 
      with essential hypertension were significantly increased compared with the 
      control group. The density of lymphocyte beta-AR and the content of 
      intralymphocyte cAMP of peripheral blood in the normal morphology, concentric 
      remodeling, and concentric hypertrophy groups were significantly higher than 
      those in the control group, while the values in the eccentric hypertrophy group 
      were significantly lower than those in the control group. Among the 4 groups, the 
      plasma levels of NE and E had increased the most in the normal morphology group, 
      followed in decreasing order by the concentric remodeling, concentric 
      hypertrophy, and eccentric hypertrophy groups; the density of lymphocyte beta-AR 
      and the content of intralymphocyte cAMP of peripheral blood in the normal 
      morphology, concentric remodeling, and concentric hypertrophy groups increased 
      while they decreased in the eccentric hypertrophy group in patients with 
      essential hypertension. The catecholamine beta-adrenergic system appears to be 
      related to left ventricular remodeling of hypertension. In this process, 
      catecholamines increased continually. The density of beta-AR and the content of 
      cAMP in peripheral lymphocytes increased at first and then decreased.
FAU - Yingxin, Peng
AU  - Yingxin P
AD  - Department of Cardiology, Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Jiang, Shan
AU  - Jiang S
FAU - Xiaoyong, Qi
AU  - Xiaoyong Q
FAU - Hao, Xue
AU  - Hao X
FAU - Chunli, Rong
AU  - Chunli R
FAU - Dongmei, Yao
AU  - Dongmei Y
FAU - Zhiqin, Guo
AU  - Zhiqin G
FAU - Shiling, Zheng
AU  - Shiling Z
FAU - Min, Wu
AU  - Min W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
RN  - 0 (Receptors, Adrenergic, beta)
RN  - E0399OZS9N (Cyclic AMP)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cyclic AMP/*blood
MH  - Echocardiography
MH  - Epinephrine/*blood
MH  - Humans
MH  - Hypertension/blood/diagnostic imaging/*physiopathology
MH  - Lymphocytes/chemistry
MH  - Male
MH  - Middle Aged
MH  - Norepinephrine/*blood
MH  - Receptors, Adrenergic, beta/*blood
MH  - *Ventricular Remodeling
EDAT- 2004/04/20 05:00
MHDA- 2004/06/02 05:00
CRDT- 2004/04/20 05:00
PHST- 2004/04/20 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2004/04/20 05:00 [entrez]
AID - 10.1536/jhj.45.285 [doi]
PST - ppublish
SO  - Jpn Heart J. 2004 Mar;45(2):285-96. doi: 10.1536/jhj.45.285.