PMID- 15090937
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20190917
IS  - 0362-5664 (Print)
IS  - 0362-5664 (Linking)
VI  - 27
IP  - 1
DP  - 2004 Jan-Feb
TI  - ADRIS - The Adverse Drug Reactions Information Scheme.
PG  - 44-8
AB  - Under the Adverse Drug Reactions Information Scheme (ADRIS) data and knowledge 
      relevant to the etiology of adverse drug reactions (ADRs) such as chemical 
      structure of parent compounds, metabolites, covalent adducts, nucleic acid and 
      protein sequences, protein structures, pharmaco-, toxico- and enzyme kinetics, 
      pharmaco- and toxicodynamics, protein interactions, molecular pathways and 
      complexes, as well as toxicological and clinical outcomes, are collected and 
      logically and semantically related. ADRIS reflects the ontological prerequisite 
      for the creation of databases and knowledge discovery systems for the abstraction 
      and visualization of theragenomic concepts. A final outcome is the prediction of 
      ADRs based on a profound knowledge of drug function and the molecular basics for 
      personalized drug safety and eventually, personalized medicine. 2004
FAU - Hug, Hubert
AU  - Hug H
AD  - TheraSTrat AG, Gewerbestrasse 25, 4123 Allschwil, Switzerland.
FAU - Bagatto, Dario
AU  - Bagatto D
FAU - Dannecker, Robert
AU  - Dannecker R
FAU - Schindler, Richard
AU  - Schindler R
FAU - Horlacher, Oliver
AU  - Horlacher O
FAU - Gut, Joseph
AU  - Gut J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Neuropharmacol
JT  - Clinical neuropharmacology
JID - 7607910
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 144O8QL0L1 (Diclofenac)
RN  - EC 1.14.13.- (CYP2C9 protein, human)
RN  - EC 1.14.13.- (Cytochrome P-450 CYP2C9)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
SB  - IM
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse 
      effects/chemistry/metabolism/therapeutic use
MH  - Aryl Hydrocarbon Hydroxylases/chemistry/metabolism
MH  - Cytochrome P-450 CYP2C9
MH  - Database Management Systems/*supply & distribution
MH  - Diclofenac/adverse effects/chemistry/metabolism/therapeutic use
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
EDAT- 2004/04/20 05:00
MHDA- 2004/06/02 05:00
CRDT- 2004/04/20 05:00
PHST- 2004/04/20 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2004/04/20 05:00 [entrez]
AID - 00002826-200401000-00012 [pii]
AID - 10.1097/00002826-200401000-00012 [doi]
PST - ppublish
SO  - Clin Neuropharmacol. 2004 Jan-Feb;27(1):44-8. doi: 
      10.1097/00002826-200401000-00012.