PMID- 15095096
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20151119
IS  - 0340-3696 (Print)
IS  - 0340-3696 (Linking)
VI  - 296
IP  - 1
DP  - 2004 Jun
TI  - Serum matrix metalloproteinase-3 in systemic sclerosis.
PG  - 25-9
AB  - To determine the serum levels of matrix metalloproteinase-3 (MMP-3) in patients 
      with systemic sclerosis (SSc) and investigate their clinical significance in this 
      disease, serum samples from 83 patients with SSc and 30 healthy volunteers were 
      examined by a specific enzyme-linked immunosorbent assay (ELISA). There was no 
      significant difference in serum levels of MMP-3 between SSc patients and healthy 
      controls. However, in female patients, there was a significant difference in 
      serum MMP-3 levels between patients subsequently developing accompanying 
      rheumatoid arthritis (RA) and those not developing RA, and patients with 
      increased levels of MMP-3 were more likely to develop RA than those with normal 
      MMP-3 levels. Additionally, arthralgia, elevated CRP, and elevated rheumatoid 
      factor were seen significantly more frequently in patients with increased MMP-3 
      levels than in those with normal MMP-3 levels. These results suggest that 
      increased serum MMP-3 is a marker for developing RA in SSc patients. SSc patients 
      with increased serum MMP-3 levels need to be followed up carefully because of the 
      risk of developing overlapping RA.
FAU - Jinnin, Masatoshi
AU  - Jinnin M
AD  - Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 
      Bunkyo-Ku, 113-8655 Tokyo, Japan.
FAU - Ihn, Hironobu
AU  - Ihn H
FAU - Asano, Yoshihide
AU  - Asano Y
FAU - Yamane, Kenichi
AU  - Yamane K
FAU - Yazawa, Norihito
AU  - Yazawa N
FAU - Tamaki, Kunihiko
AU  - Tamaki K
LA  - eng
PT  - Journal Article
DEP - 20040417
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9009-79-4 (Rheumatoid Factor)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Arthralgia/etiology
MH  - Arthritis, Rheumatoid/etiology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Rheumatoid Factor/blood
MH  - Scleroderma, Systemic/*blood/complications
EDAT- 2004/04/20 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/04/20 05:00
PHST- 2003/04/16 00:00 [received]
PHST- 2004/02/18 00:00 [revised]
PHST- 2004/03/13 00:00 [accepted]
PHST- 2004/04/20 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/04/20 05:00 [entrez]
AID - 10.1007/s00403-004-0468-1 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2004 Jun;296(1):25-9. doi: 10.1007/s00403-004-0468-1. Epub 
      2004 Apr 17.