PMID- 15095782
OWN - NLM
STAT- MEDLINE
DCOM- 20041022
LR  - 20171116
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 50
IP  - 2
DP  - 2004 Mar
TI  - Innate immune and non-immune mediators of erythrocyte clearance.
PG  - 107-16
AB  - Erythrocyte clearance is reviewed in the context of what is known in 2003 on 
      clearance of apoptotic cells in vitro and in vivo. Thus, emphasis is put on the 
      role of the innate immune system comprised of naturally occurring autoantibodies 
      (NAbs) and complement. Oxidative damage, cellular senescence and 
      diffusion-controlled exoplasmic cross-linking appear to generate oligomers of 
      band 3 (anion transport protein) that are a prerequisite for anti-band 3 NAb 
      binding to human red blood cells (RBC). Similar processes seem to be responsible 
      for premature RBC clearance in hemoglobinopathies and membrane protein 
      deficiencies. The review discusses why NAb binding alone is insufficient and how 
      bound NAbs may enhance complement deposition. Clearance of RBC is not only the 
      result of cell-bound opsonins, but is enhanced by the loss of RBC membrane 
      constituents, such as CD47 and sialic acids. As long as these constituents are 
      present on RBC in normal numbers and topologic arrangement, they bind to their 
      respective receptors on macrophages, elicit a negative signal that appears to 
      prevent the macrophage from engulfing bound RBC. Exposure of phosphatidylserine 
      is not a primary signal for RBC removal and where exposed it initiates binding of 
      CRP or of beta-2-glycoprotein I and NAbs.
FAU - Lutz, H U
AU  - Lutz HU
AD  - Institute of Biochemistry, Swiss Federal Institute of Technology, 
      ETH-Hoenggerberg, Schafmattstr. 18, HPM D 14.1, CH 8093 Zurich, Switzerland. 
      hans.lutz@bc.biol.ethz.ch
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Anion Exchange Protein 1, Erythrocyte)
RN  - 0 (Antigens, CD)
RN  - 0 (Autoantibodies)
RN  - 0 (CD47 Antigen)
RN  - 0 (CD47 protein, human)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Anion Exchange Protein 1, Erythrocyte/immunology
MH  - Antigens, CD/immunology
MH  - Autoantibodies/blood
MH  - CD47 Antigen
MH  - Erythrocyte Membrane/immunology
MH  - Erythrocytes/*immunology/*physiology
MH  - Humans
MH  - Immunity, Innate/*immunology
MH  - N-Acetylneuraminic Acid/immunology
RF  - 125
EDAT- 2004/04/21 05:00
MHDA- 2004/10/23 09:00
CRDT- 2004/04/21 05:00
PHST- 2004/04/21 05:00 [pubmed]
PHST- 2004/10/23 09:00 [medline]
PHST- 2004/04/21 05:00 [entrez]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 2004 Mar;50(2):107-16.