PMID- 15096322 OWN - NLM STAT- MEDLINE DCOM- 20041005 LR - 20051116 IS - 0949-2321 (Print) IS - 0949-2321 (Linking) VI - 9 IP - 3 DP - 2004 Mar 30 TI - Low molecular weight heparins as thromboprophylaxis in patients undergoing hemodialysis/hemofiltration or continuous renal replacement therapies. PG - 125-30 AB - Low molecular weight heparins (LMWHs) have potential advantages over unfractionated heparin (UFH). They interact less with platelets and may induce less bleeding. The risk for heparin induced thrombocytopenia is less, and the effect on serum lipids is favourable. The half-life is longer, allowing for one single bolus dose at start of hemodialysis (HD). In addition, LMWH is found to result in lower plasma potassium in HD patients compared to UFH. LMWHs have an established role in HD and hemofiltration (HF), but the reports on their efficacy and safety during continuous renal replacement therapy (CRRT) are scarce. FAU - Sagedal, Solbjorg AU - Sagedal S AD - Department of Medicine, Rikshospitalet University Hospital, N-0027 Oslo, Norway. solbjorg.sagedal@rikshospitalet.no FAU - Hartmann, Anders AU - Hartmann A LA - eng PT - Journal Article PT - Review PL - England TA - Eur J Med Res JT - European journal of medical research JID - 9517857 RN - 0 (Anticoagulants) RN - 0 (Heparin, Low-Molecular-Weight) SB - IM MH - Anticoagulants/*therapeutic use MH - *Hemofiltration MH - Heparin, Low-Molecular-Weight/*therapeutic use MH - Humans MH - *Renal Dialysis MH - Thrombosis/physiopathology/*prevention & control RF - 45 EDAT- 2004/04/21 05:00 MHDA- 2004/10/06 09:00 CRDT- 2004/04/21 05:00 PHST- 2004/04/21 05:00 [pubmed] PHST- 2004/10/06 09:00 [medline] PHST- 2004/04/21 05:00 [entrez] PST - ppublish SO - Eur J Med Res. 2004 Mar 30;9(3):125-30.