PMID- 15099927
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20191210
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 77
IP  - 4
DP  - 2004 Apr
TI  - The effects of MDMA pretreatment on the behavioural effects of other drugs of 
      abuse in the rat elevated plus-maze test.
PG  - 805-14
AB  - Few preclinical studies have found long-term behavioural consequences of the 
      serotonergic neurotoxicity produced by 3,4-methylenedioxymethamphetamine (MDMA). 
      This study investigated whether pretreatment with MDMA altered the behavioural 
      effects of other drugs of abuse. Adult male Lister hooded rats (n=10/group) were 
      pretreated with 10 mg/kg MDMA or 1 ml/kg saline vehicle intraperitoneally every 2 
      h for 6 h. Fourteen days later, the behavioural effects of d-amphetamine (2 
      mg/kg), cocaine (10 mg/kg), ethanol (2.0 g/kg), heroin (0.5 mg/kg), or MDMA (10 
      mg/kg) were assessed in the elevated plus-maze test. MDMA pretreatment produced 
      approximately 20-25% decrease in hippocampal 5-HT and 5-HIAA concentrations, and 
      [(3)H]paroxetine binding when analysed 2 weeks later. Despite inducing 
      neurotoxicity, this regimen had no effect upon the plus-maze behaviour induced by 
      ethanol, heroin, and MDMA. Acutely, and independent of neurotoxic pretreatment, 
      MDMA produced a clear anxiogenic-like behavioural profile with a reduction of 
      open arm entries and suppression of explorative behaviours. Despite being acutely 
      anxiogenic, pretreatment with a neurotoxic regimen of MDMA has little effect on 
      the anxiety-related effects of other drugs of abuse. It is possible that extended 
      time points would produce significant changes, although the available evidence 
      suggests that the plus-maze may not be a suitable model for detection of 
      behavioural dysfunction after neurotoxic MDMA.
FAU - Sumnall, H R
AU  - Sumnall HR
AD  - Department of Psychology, Eleanor Rathbone Building, University of Liverpool, 
      Liverpool L69 7ZA, UK.
FAU - O'Shea, E
AU  - O'Shea E
FAU - Marsden, C A
AU  - Marsden CA
FAU - Cole, J C
AU  - Cole JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Illicit Drugs)
RN  - 41VRH5220H (Paroxetine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anxiety/metabolism
MH  - Drug Interactions
MH  - Hippocampus/drug effects/metabolism
MH  - Illicit Drugs/metabolism/*pharmacology
MH  - Male
MH  - Maze Learning/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/metabolism
MH  - Paroxetine/metabolism
MH  - Protein Binding/physiology
MH  - Rats
EDAT- 2004/04/22 05:00
MHDA- 2004/11/17 09:00
CRDT- 2004/04/22 05:00
PHST- 2003/12/15 00:00 [received]
PHST- 2004/02/13 00:00 [revised]
PHST- 2004/02/13 00:00 [accepted]
PHST- 2004/04/22 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/04/22 05:00 [entrez]
AID - S0091305704000577 [pii]
AID - 10.1016/j.pbb.2004.02.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Apr;77(4):805-14. doi: 10.1016/j.pbb.2004.02.007.