PMID- 15100022
OWN - NLM
STAT- MEDLINE
DCOM- 20040617
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1655
IP  - 1-3
DP  - 2004 Apr 12
TI  - Surface-mediated proton-transfer reactions in membrane-bound proteins.
PG  - 102-15
AB  - As outlined by Peter Mitchell in the chemiosmotic theory, an intermediate in 
      energy conversion in biological systems is a proton electrochemical potential 
      difference ("proton gradient") across a membrane, generated by membrane-bound 
      protein complexes. These protein complexes accommodate proton-transfer pathways 
      through which protons are conducted. In this review, we focus specifically on the 
      role of the protein-membrane surface and the surface-bulk water interface in the 
      dynamics of proton delivery to these proton-transfer pathways. The general 
      mechanisms are illustrated by experimental results from studies of bacterial 
      photosynthetic reaction centres (RCs) and cytochrome c oxidase (CcO).
FAU - Adelroth, Pia
AU  - Adelroth P
AD  - Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural 
      Sciences, Stockholm University, Svante Arrhenius vag 12, SE-106 91 Stockholm, 
      Sweden. piaa@dbb.su.se
FAU - Brzezinski, Peter
AU  - Brzezinski P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Membrane Proteins)
RN  - 0 (Photosynthetic Reaction Center Complex Proteins)
RN  - 059QF0KO0R (Water)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Electron Transport
MH  - Electron Transport Complex IV/chemistry/genetics/metabolism
MH  - Kinetics
MH  - Membrane Proteins/*chemistry/*metabolism
MH  - Models, Molecular
MH  - Mutagenesis, Site-Directed
MH  - Photosynthetic Reaction Center Complex Proteins/chemistry/genetics/metabolism
MH  - Proton-Motive Force
MH  - Rhodobacter sphaeroides/enzymology/genetics
MH  - Water/metabolism
RF  - 86
EDAT- 2004/04/22 05:00
MHDA- 2004/06/18 05:00
CRDT- 2004/04/22 05:00
PHST- 2003/10/22 00:00 [received]
PHST- 2003/10/22 00:00 [accepted]
PHST- 2004/04/22 05:00 [pubmed]
PHST- 2004/06/18 05:00 [medline]
PHST- 2004/04/22 05:00 [entrez]
AID - S0005272803002366 [pii]
AID - 10.1016/j.bbabio.2003.10.018 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2004 Apr 12;1655(1-3):102-15. doi: 
      10.1016/j.bbabio.2003.10.018.