PMID- 15101734
OWN - NLM
STAT- MEDLINE
DCOM- 20040728
LR  - 20191108
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 45
IP  - 2
DP  - 2004 Feb
TI  - Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: 
      a diagnostic and treatment dilemma.
PG  - 409-14
AB  - We report a rare case of small cell carcinoma (SCC) of lung, metastatic to 
      ipsilateral hilar and peribronchial lymph nodes with synchronous mantle cell 
      lymphoma (MCL), in a 58-year-old female. She was treated with Cisplatin, 
      Etoposide, and Rituximab, and remained in complete remission for approximately 
      two and a half years following the initial diagnosis. To the best of our 
      knowledge, synchronous SCC and MCL or SCC metastatic to lymph nodes involved by 
      MCL has not been previously reported. In this case, the features of MCL were very 
      inconspicuous in the lymph nodes with extensive metastases of SCC. The presence 
      of MCL was confirmed by immunohistochemistry and fluorescence in situ 
      hybridization (FISH). The co-existence of lymphoma and metastatic carcinoma in 
      the same lymph node, as seen in this case, highlights the significance of 
      analyzing subtle lymphoid architectural changes, and applying ancillary studies 
      such as immunohistochemistry and molecular analysis in suspicious cases. The 
      management of synchronous SCC and MCL requires consideration of their respective 
      biologic behavior, and cumulative toxicity of treatment regimens of both tumors. 
      In such cases an optimum treatment strategy should be adopted to cover both 
      malignancies with minimal toxic effect.
FAU - Kampalath, Bal
AU  - Kampalath B
AD  - Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 
      53226, USA. bkampal@yahoo.com
FAU - Abed, Nashwa
AU  - Abed N
FAU - Chitambar, Christopher R
AU  - Chitambar CR
FAU - Vantuinen, Peter
AU  - Vantuinen P
FAU - Chakrabarty, Gargi
AU  - Chakrabarty G
FAU - Hanson, Gerald
AU  - Hanson G
FAU - Rao, R Nagarjun
AU  - Rao RN
FAU - Shidham, Vinod B
AU  - Shidham VB
FAU - Chang, Chung-Che
AU  - Chang CC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Antigens, CD20)
RN  - 0 (CD3 Complex)
RN  - 4F4X42SYQ6 (Rituximab)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Antibodies, Monoclonal, Murine-Derived
MH  - Antigens, CD20/biosynthesis
MH  - CD3 Complex/biosynthesis
MH  - Carcinoma, Small Cell/*diagnosis/pathology/therapy
MH  - Cisplatin/therapeutic use
MH  - Etoposide/therapeutic use
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*diagnosis/pathology/therapy
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Lymphoma, Mantle-Cell/*diagnosis/pathology/therapy
MH  - Middle Aged
MH  - Remission Induction
MH  - Rituximab
EDAT- 2004/04/23 05:00
MHDA- 2004/07/29 05:00
CRDT- 2004/04/23 05:00
PHST- 2004/04/23 05:00 [pubmed]
PHST- 2004/07/29 05:00 [medline]
PHST- 2004/04/23 05:00 [entrez]
AID - 10.1080/1042819031000149395 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2004 Feb;45(2):409-14. doi: 10.1080/1042819031000149395.