PMID- 15103707
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20131121
IS  - 0269-3879 (Print)
IS  - 0269-3879 (Linking)
VI  - 18
IP  - 3
DP  - 2004 Apr
TI  - High-performance liquid chromatography with fluorescence detection for the 
      simultaneous determination of 3,4-methylenedioxymethamphetamine, methamphetamine 
      and their metabolites in human hair using DIB-Cl as a label.
PG  - 202-4
AB  - This paper describes a highly sensitive HPLC method for the simultaneous 
      determination of 3,4-methylenedioxymethamphetamine (MDMA), 
      3,4-methylenedioxyamphetamine (MDA), amphetamine (AP) and methamphetamine (MP) in 
      human hair samples. The amphetamines investigated were derivatized with the 
      fluorescent reagent, DIB-Cl to yield highly fluorescent DIB-derivatives, which 
      were then analyzed by HPLC with fluorescence detection at excitation and emission 
      wavelengths of 325 nm and 430 nm, respectively. The separation was achieved on an 
      ODS column with an isocratic mobile phase composed of acetonitrile-methanol-water 
      (30:40:30, v/v/v). The limits of detection for the four compounds obtained by the 
      proposed method ranged from 11 to 200 pg/mg. The method was successfully applied 
      to the determination of MDMA and MDA in hair samples obtained from MDMA abuser.
CI  - Copyright 2004 John Wiley & Sons, Ltd.
FAU - Kaddoumi, Amal
AU  - Kaddoumi A
AD  - Division of Analytical Research for Pharmacoinformatics, Department of Clinical 
      Pharmacy, Course of Pharmaceutical Sciences, Graduate School of Biomedical 
      Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
FAU - Kikura-Hanajiri, Ruri
AU  - Kikura-Hanajiri R
FAU - Nakashima, Kenichiro
AU  - Nakashima K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analysis/metabolism
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - Methamphetamine/*analysis/metabolism
MH  - Spectrometry, Fluorescence/*methods
MH  - Substance Abuse Detection/methods
EDAT- 2004/04/23 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/04/23 05:00
PHST- 2004/04/23 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/04/23 05:00 [entrez]
AID - 10.1002/bmc.374 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2004 Apr;18(3):202-4. doi: 10.1002/bmc.374.