PMID- 15104674
OWN - NLM
STAT- MEDLINE
DCOM- 20051013
LR  - 20061115
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 5
DP  - 2004 May
TI  - HLA-B27: a registry of constitutive peptide ligands.
PG  - 424-45
AB  - The very strong association of human leukocyte antigen (HLA)-B27 with 
      spondyloarthritis might be related to its peptide-presenting properties. The 
      natural polymorphism of this molecule influences both peptide specificity and 
      disease susceptibility. In this study, we present a comprehensive compilation of 
      known natural ligands of HLA-B27 arising from endogenous proteins of human cells, 
      together with a statistical assessment of residue usage among constitutive 
      peptide repertoires of multiple HLA-B27 subtypes. This analysis provides evidence 
      that every peptide position, including "non-anchor" ones, may be subjected to 
      selection on the basis of its contribution to HLA-B27 binding and also allows a 
      quantization of residue preferences at known anchor positions. The present 
      registry is intended as a basis on which to build up reliable criteria to assess 
      the effect of HLA-B27 polymorphism on peptide presentation, for T-cell epitope 
      predictions, and for molecular mimicry studies.
FAU - Lopez de Castro, J A
AU  - Lopez de Castro JA
AD  - Centro de Biologia Molecular Severo Ochoa (Consejo Superior de Investigaciones 
      Cientificas and Universidad Autonoma de Madrid), Universidad Autonoma, 28049 
      Madrid, Spain. aldecastro@cbm.uam.es
FAU - Alvarez, I
AU  - Alvarez I
FAU - Marcilla, M
AU  - Marcilla M
FAU - Paradela, A
AU  - Paradela A
FAU - Ramos, M
AU  - Ramos M
FAU - Sesma, L
AU  - Sesma L
FAU - Vazquez, M
AU  - Vazquez M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Ligands)
RN  - 0 (Peptides)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigen Presentation
MH  - Cell Line
MH  - Cell Transformation, Viral
MH  - Data Interpretation, Statistical
MH  - Databases, Factual
MH  - HLA-B27 Antigen/*genetics/immunology
MH  - Herpesvirus 4, Human
MH  - Humans
MH  - Ligands
MH  - Molecular Sequence Data
MH  - Peptides/*genetics/immunology
MH  - Polymorphism, Genetic
MH  - Protein Binding
MH  - Spondylarthritis/immunology
EDAT- 2004/04/24 05:00
MHDA- 2005/10/14 09:00
CRDT- 2004/04/24 05:00
PHST- 2004/04/24 05:00 [pubmed]
PHST- 2005/10/14 09:00 [medline]
PHST- 2004/04/24 05:00 [entrez]
AID - TAN220 [pii]
AID - 10.1111/j.0001-2815.2004.00220.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 May;63(5):424-45. doi: 10.1111/j.0001-2815.2004.00220.x.