PMID- 15104676
OWN - NLM
STAT- MEDLINE
DCOM- 20051013
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 5
DP  - 2004 May
TI  - Identification of a MAGE-1 peptide recognized by cytolytic T lymphocytes on 
      HLA-B*5701 tumors.
PG  - 453-7
AB  - "Cancer germline" genes such as those of the MAGE family are expressed in many 
      tumors and in male germline cells but are silent in normal tissues. They encode 
      shared tumor-specific antigens that have been used in therapeutic vaccination 
      trials of cancer patients. We report the identification of a new MAGE-1-encoded 
      peptide that is recognized by a cytolytic T-lymphocyte (CTL) clone on human 
      leukocyte antigen (HLA)-B*5701. The sequence of the peptide, corresponding to 
      position 102-112 of the MAGE-1 protein sequence, is ITKKVADLVGF. When tumor cells 
      expressing MAGE-1 were transfected with HLA-B*5701, they were lyzed by the CTL 
      clone, indicating that the peptide is processed in tumor cells and can, 
      therefore, be used as a target for anti-tumoral vaccination.
FAU - Corbiere, V
AU  - Corbiere V
AD  - Institute of Cellular Pathology, Cellular Genetics Unit, Universite de Louvain, 
      B-1200 Brussels, Belgium.
FAU - Nicolay, H
AU  - Nicolay H
FAU - Russo, V
AU  - Russo V
FAU - Stroobant, V
AU  - Stroobant V
FAU - Brichard, V
AU  - Brichard V
FAU - Boon, T
AU  - Boon T
FAU - van der Bruggen, P
AU  - van der Bruggen P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA-B Antigens)
RN  - 0 (MAGEA1 protein, human)
RN  - 0 (Melanoma-Specific Antigens)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Peptides)
SB  - IM
MH  - Antigens, Neoplasm/genetics/*immunology
MH  - Base Sequence
MH  - Cell Line, Tumor
MH  - Cell Transformation, Viral
MH  - HLA-B Antigens/*immunology
MH  - Herpesvirus 4, Human
MH  - Humans
MH  - Melanoma-Specific Antigens
MH  - Neoplasm Proteins/genetics/*immunology
MH  - Peptides/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 2004/04/24 05:00
MHDA- 2005/10/14 09:00
CRDT- 2004/04/24 05:00
PHST- 2004/04/24 05:00 [pubmed]
PHST- 2005/10/14 09:00 [medline]
PHST- 2004/04/24 05:00 [entrez]
AID - TAN203 [pii]
AID - 10.1111/j.0001-2815.2004.00203.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 May;63(5):453-7. doi: 10.1111/j.0001-2815.2004.00203.x.