PMID- 1510677
OWN - NLM
STAT- MEDLINE
DCOM- 19920918
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 186
IP  - 3
DP  - 1992 Aug 14
TI  - PDGF AA homodimers are potent chemoattractants for fibroblasts and neutrophils, 
      and for monocytes activated by lymphocytes or cytokines.
PG  - 1510-4
AB  - The A-chain homodimers of the platelet-derived growth factor (PDGF AA) are widely 
      expressed in normal and transformed cells. The mitogenic properties of PDGF AA 
      are well established; however, the chemotactic potential of PDGF AA remains 
      controversial. We now show that PDGF AA is a strong chemoattractant for human 
      monocytes, granulocytes, and fetal bovine ligament fibroblasts. However, highly 
      purified (greater than 98%) monocytes require the addition of lymphocytes or IL-1 
      for chemotactic responsiveness to PDGF AA but not for full chemotactic activity 
      with formyl-methionyl-leucyl-phenylalanine (fMLP) or C5a. These results indicate 
      that PDGF AA is a potent chemoattractant. These results also indicate that 
      monocytes require activation either by lymphocytes or exogenous cytokines in 
      order to respond chemotactically to PDGF AA but not to fMLP or C5a and suggest 
      roles of the lymphocyte and cytokine in the chemotactic response of the monocyte 
      to PDGF AA in vivo.
FAU - Shure, D
AU  - Shure D
AD  - Pulmonary Section, VA Medical Center, San Diego, CA 92161.
FAU - Senior, R M
AU  - Senior RM
FAU - Griffin, G L
AU  - Griffin GL
FAU - Deuel, T F
AU  - Deuel TF
LA  - eng
GR  - CA49712/CA/NCI NIH HHS/United States
GR  - HL14147/HL/NHLBI NIH HHS/United States
GR  - HL31102/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Interleukin-1)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cells, Cultured
MH  - Chemotaxis/drug effects/*physiology
MH  - Chemotaxis, Leukocyte/drug effects/*physiology
MH  - Fetus
MH  - Fibroblasts/drug effects/physiology
MH  - Humans
MH  - Interleukin-1/pharmacology
MH  - Macromolecular Substances
MH  - Monocytes/drug effects/*physiology
MH  - Neutrophils/drug effects/*physiology
MH  - Platelet-Derived Growth Factor/*pharmacology
MH  - Recombinant Proteins/pharmacology
EDAT- 1992/08/14 00:00
MHDA- 1992/08/14 00:01
CRDT- 1992/08/14 00:00
PHST- 1992/08/14 00:00 [pubmed]
PHST- 1992/08/14 00:01 [medline]
PHST- 1992/08/14 00:00 [entrez]
AID - S0006-291X(05)81577-3 [pii]
AID - 10.1016/s0006-291x(05)81577-3 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1992 Aug 14;186(3):1510-4. doi: 
      10.1016/s0006-291x(05)81577-3.