PMID- 1511295
OWN - NLM
STAT- MEDLINE
DCOM- 19920929
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 585
IP  - 1-2
DP  - 1992 Jul 10
TI  - Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine 
      and its metabolites in the nucleus accumbens and prefrontal cortex in the rat.
PG  - 1-6
AB  - To determine the influence of neurons of the ventral hippocampus on dopamine (DA) 
      turnover in other limbic areas, spontaneous and amphetamine-induced locomotion as 
      well as DA and its metabolites were assayed in nucleus accumbens, medial 
      prefrontal cortex and anteromedial striatum, 14 and 28 days after bilateral 
      ibotenic acid (IA) or sham lesions of the ventral hippocampus in the rat. 
      Spontaneous locomotion was increased 28 days postoperatively, while D-amphetamine 
      induced locomotion was augmented both 14 and 28 days postoperatively in IA 
      lesioned animals. DA levels in the nucleus accumbens were decreased on the 14th, 
      but increased on the 28th day after the lesion. Dihydroxyphenylacetic acid 
      (DOPAC), homovanillic acid (HVA) and the DOPAC/DA ratio in the medial prefrontal 
      cortex (MPFC) were reduced 28 days postoperatively. Moreover, there was a 
      significant negative correlation between the DOPAC/DA ratio in the MPFC and DA 
      levels in the nucleus accumbens at this time point. These data indicate that a 
      lesion of the ventral hippocampus can produce differential changes in cortical 
      and limbic DA activity. Implications for an animal model of schizophrenia are 
      considered.
FAU - Lipska, B K
AU  - Lipska BK
AD  - Clinical Brain Disorders Branch, National Institute of Mental Health, Washington, 
      DC.
FAU - Jaskiw, G E
AU  - Jaskiw GE
FAU - Chrapusta, S
AU  - Chrapusta S
FAU - Karoum, F
AU  - Karoum F
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 2552-55-8 (Ibotenic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Dopamine/*metabolism
MH  - Frontal Lobe/*metabolism
MH  - Hippocampus/*physiology
MH  - Ibotenic Acid
MH  - Male
MH  - Nucleus Accumbens/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Time Factors
EDAT- 1992/07/10 00:00
MHDA- 1992/07/10 00:01
CRDT- 1992/07/10 00:00
PHST- 1992/07/10 00:00 [pubmed]
PHST- 1992/07/10 00:01 [medline]
PHST- 1992/07/10 00:00 [entrez]
AID - 0006-8993(92)91184-G [pii]
AID - 10.1016/0006-8993(92)91184-g [doi]
PST - ppublish
SO  - Brain Res. 1992 Jul 10;585(1-2):1-6. doi: 10.1016/0006-8993(92)91184-g.