PMID- 15115868
OWN - NLM
STAT- MEDLINE
DCOM- 20040524
LR  - 20190503
IS  - 0040-6376 (Print)
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 59
IP  - 5
DP  - 2004 May
TI  - Involvement of dendritic cells in sarcoidosis.
PG  - 408-13
AB  - BACKGROUND: Sarcoidosis is a systemic granulomatous disease of unknown aetiology. 
      It has been suggested that T helper type 1 (Th1) polarisation is associated with 
      the pathophysiology of sarcoidosis, but the mechanism of skewing towards Th1 has 
      not been elucidated. Dendritic cells (DCs) are known to regulate immune 
      responses. This study was performed to determine whether DCs are involved in the 
      aetiology of sarcoidosis. METHODS: The numbers of peripheral blood DCs in 24 
      patients with sarcoidosis were analysed and biopsy specimens from four patients 
      were stained immunohistochemically using monoclonal antibodies. RESULTS: The 
      numbers of both myeloid and lymphoid DC subsets were significantly decreased in 
      the blood and mature DCs were found in the granulomas of patients with 
      sarcoidosis. A number of interferon-gamma (IFN-gamma) producing T cells were also 
      detected in the sarcoid granuloma, as well as many interleukin (IL)-4 producing T 
      cells. Double staining of the biopsy specimen using anti-fascin and anti-CD3 
      antibodies showed an anatomical interaction between DCs and T cells. CONCLUSIONS: 
      These findings suggest that the blood DC subsets may migrate into the affected 
      tissues, contributing to the formation of the granulomas in sarcoidosis. It is 
      hypothesised that the migrating DCs may regulate the T cell response in 
      sarcoidosis, at least in the granulomatous lesions.
FAU - Ota, M
AU  - Ota M
AD  - First Department of Internal Medicine, Kansai Medical University, 10-15 
      Fumizono-cho, Moriguchi, Osaka 570-8506, Japan.
FAU - Amakawa, R
AU  - Amakawa R
FAU - Uehira, K
AU  - Uehira K
FAU - Ito, T
AU  - Ito T
FAU - Yagi, Y
AU  - Yagi Y
FAU - Oshiro, A
AU  - Oshiro A
FAU - Date, Y
AU  - Date Y
FAU - Oyaizu, H
AU  - Oyaizu H
FAU - Shigeki, T
AU  - Shigeki T
FAU - Ozaki, Y
AU  - Ozaki Y
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Uemura, Y
AU  - Uemura Y
FAU - Yonezu, S
AU  - Yonezu S
FAU - Fukuhara, S
AU  - Fukuhara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dendritic Cells/*pathology
MH  - Female
MH  - Granuloma/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis/*pathology
MH  - Statistics, Nonparametric
PMC - PMC1746987
EDAT- 2004/04/30 05:00
MHDA- 2004/05/25 05:00
PMCR- 2007/05/01
CRDT- 2004/04/30 05:00
PHST- 2004/04/30 05:00 [pubmed]
PHST- 2004/05/25 05:00 [medline]
PHST- 2004/04/30 05:00 [entrez]
PHST- 2007/05/01 00:00 [pmc-release]
AID - 10.1136/thx.2003.006049 [doi]
PST - ppublish
SO  - Thorax. 2004 May;59(5):408-13. doi: 10.1136/thx.2003.006049.