PMID- 15116369
OWN - NLM
STAT- MEDLINE
DCOM- 20040604
LR  - 20061115
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 29
IP  - 5
DP  - 2004 May
TI  - Different short-term modulation of cortical motor output to distal and proximal 
      upper-limb muscles during painful sensory nerve stimulation.
PG  - 663-9
AB  - The pattern of upper-limb muscle activation following painful stimulation has not 
      been clarified in detail. We investigated the short-term inhibitory and 
      excitatory effects of painful electrical digital stimulation on the motoneuron 
      pools of distal and proximal upper-limb muscles. Transcranial magnetic 
      stimulation (TMS) was used as test stimulus, and painful digital nerve 
      stimulation as conditioning stimulus for motor evoked potential (MEP) recordings 
      over the abductor digiti minimi (ADM), abductor pollicis brevis (APB), biceps 
      brachii (BB), and deltoid muscles. Inhibition of the conditioned MEP response was 
      most prominent in the distal muscles, whereas BB and deltoid muscles were only 
      weakly inhibited. The mean MEP response over APB decreased with painful cutaneous 
      stimuli, showing maximum inhibition (by 82%) at interstimulus intervals (ISIs) of 
      50 ms. Inhibition in the ADM was maximal (49%) but less pronounced at an ISI of 
      40 ms. The BB and deltoid muscles showed inhibition by 25% and 29%, respectively. 
      Significant facilitation was present in BB and deltoid muscles by 43% and 41% at 
      an ISI of 100 ms, but not in the smaller hand muscles. The observed pattern of 
      upper-limb muscle activation corresponds to the protective withdrawal reflex and 
      the neuronal basis of the observed short-term modulation of motor activity is 
      compatible with a spinal or brainstem pathway.
FAU - Urban, P P
AU  - Urban PP
AD  - Department of Neurology, University of Mainz, Langenbeckstrasse 1, D-55101 Mainz, 
      Germany. urban@neurologie.klinik.uni-mainz.de
FAU - Solinski, M
AU  - Solinski M
FAU - Best, C
AU  - Best C
FAU - Rolke, R
AU  - Rolke R
FAU - Hopf, H C
AU  - Hopf HC
FAU - Dieterich, M
AU  - Dieterich M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Arm/*physiology
MH  - Electric Stimulation/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Cortex/physiology
MH  - Muscle, Skeletal/*physiology
MH  - Neurons, Afferent/*physiology
MH  - Pain/*physiopathology
MH  - Time Factors
EDAT- 2004/04/30 05:00
MHDA- 2004/06/05 05:00
CRDT- 2004/04/30 05:00
PHST- 2004/04/30 05:00 [pubmed]
PHST- 2004/06/05 05:00 [medline]
PHST- 2004/04/30 05:00 [entrez]
AID - 10.1002/mus.20011 [doi]
PST - ppublish
SO  - Muscle Nerve. 2004 May;29(5):663-9. doi: 10.1002/mus.20011.