PMID- 15118245
OWN - NLM
STAT- MEDLINE
DCOM- 20041108
LR  - 20220321
IS  - 0916-8818 (Print)
IS  - 0916-8818 (Linking)
VI  - 50
IP  - 2
DP  - 2004 Apr
TI  - Anesthesia and acoustic stress-induced intra-uterine growth retardation in mice.
PG  - 185-90
AB  - Stress interferes with reproduction, adversely influencing implantation and fetal 
      growth, and sometimes even leading to abortion. Here, we attempted to evaluate 
      the early gestational effects of uncomfortable sound on pregnant mice and their 
      offspring. Ten-week-old pregnant Jcl:ICR mice were exposed to sound (100 dB, 
      random frequency between 9-34 kHz) for 8 hours on the 3(rd), 5(th) and 7(th) 
      gestational days (GD). The effects of general anesthesia were also investigated, 
      with or without acoustic stress. All groups were examined on the 18(th) GD for 
      fetal growth. Fetal weight, number of ossified sacrococcygeal vertebrae and 
      placental weight were all significantly reduced (P<0.0001) when stress was 
      induced on the 7(th) GD, but not on the 3(rd) or 5(th) GD. This intra-uterine 
      growth retardation (IUGR) was significantly inhibited by general anesthesia 
      (P<0.0001), although general anesthesia alone induced significant IUGR (P<0.0001) 
      when compared with control mice. This suggests that acoustic exposure indirectly 
      exerts an effect on fetal growth, possibly via a psycho-maternal pathway. We also 
      found that analysis of the number of ossified sacrococcygeal vertebrae is the 
      most sensitive tool for the study of IUGR.
FAU - Haque, Shanta Fahmida
AU  - Haque SF
AD  - Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai 
      University School of Medicine, Kanagawa, Japan.
FAU - Izumi, Shun-Ichiro
AU  - Izumi S
FAU - Aikawa, Hiroyuki
AU  - Aikawa H
FAU - Suzuki, Takahiro
AU  - Suzuki T
FAU - Matsubayashi, Hidehiko
AU  - Matsubayashi H
FAU - Murano, Takayo
AU  - Murano T
FAU - Kika, Goh
AU  - Kika G
FAU - Ikeda, Masae
AU  - Ikeda M
FAU - Goya, Kenichi
AU  - Goya K
FAU - Makino, Tsunehisa
AU  - Makino T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Reprod Dev
JT  - The Journal of reproduction and development
JID - 9438792
RN  - 0 (Anesthetics, Inhalation)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - *Acoustics
MH  - *Anesthesia
MH  - Anesthetics, Inhalation/*adverse effects
MH  - Animals
MH  - Bone Development/drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Growth Retardation/*chemically induced/*pathology
MH  - Fetal Weight
MH  - Isoflurane/*adverse effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Noise
MH  - Pregnancy
MH  - Pregnancy, Animal
MH  - Spine/embryology
MH  - Stress, Physiological
MH  - Time Factors
MH  - Ultrasonics
EDAT- 2004/05/01 05:00
MHDA- 2004/11/09 09:00
CRDT- 2004/05/01 05:00
PHST- 2004/05/01 05:00 [pubmed]
PHST- 2004/11/09 09:00 [medline]
PHST- 2004/05/01 05:00 [entrez]
AID - 10.1262/jrd.50.185 [doi]
PST - ppublish
SO  - J Reprod Dev. 2004 Apr;50(2):185-90. doi: 10.1262/jrd.50.185.