PMID- 15119544
OWN - NLM
STAT- MEDLINE
DCOM- 20040722
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 13
IP  - 3
DP  - 2004
TI  - Absence of association between the MCP-1 gene polymorphism and histological 
      phenotype of lupus nephritis.
PG  - 165-7
AB  - Lupus nephritis presents two polar histological patterns, diffuse proliferative 
      glomerulonephritis (DPGN) and membranous glomerulonephritis (MGN). In the kidney 
      tissue of DPGN, numerous mononuclear cells were seen in the interstitium and 
      glomeruli; on the other hand in MGN, infiltrating cells were less frequent. 
      Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for 
      monocytes, T-cells, and natural killer cells. In this study we assessed the 
      significance of the MCP-1 gene in determination of the histological phenotype in 
      lupus nephritis. There was no association between the risk of DPGN and the MCP-1 
      gene genotype.
FAU - Nakashima, H
AU  - Nakashima H
AD  - Department of Medicine and Biosystemic Science, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka, Japan. hnakashi@intmed1.med.kyushu-u.ac.jp
FAU - Akahoshi, M
AU  - Akahoshi M
FAU - Shimizu, S
AU  - Shimizu S
FAU - Inoue, Y
AU  - Inoue Y
FAU - Miyake, K
AU  - Miyake K
FAU - Ninomiya, I
AU  - Ninomiya I
FAU - Igawa, T
AU  - Igawa T
FAU - Sadanaga, A
AU  - Sadanaga A
FAU - Otsuka, T
AU  - Otsuka T
FAU - Harada, M
AU  - Harada M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Confidence Intervals
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Japan
MH  - Lupus Nephritis/*epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Phenotype
MH  - *Polymorphism, Genetic
MH  - Probability
MH  - Reference Values
MH  - Risk Assessment
MH  - Sampling Studies
MH  - Sensitivity and Specificity
EDAT- 2004/05/04 05:00
MHDA- 2004/07/23 05:00
CRDT- 2004/05/04 05:00
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/07/23 05:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
AID - 10.1191/0961203304lu523oa [doi]
PST - ppublish
SO  - Lupus. 2004;13(3):165-7. doi: 10.1191/0961203304lu523oa.