PMID- 15119959
OWN - NLM
STAT- MEDLINE
DCOM- 20040805
LR  - 20190731
IS  - 1471-5945 (Electronic)
IS  - 1471-5945 (Linking)
VI  - 4
DP  - 2004 Apr 30
TI  - Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an 
      antithyroid thioureylene.
PG  - 4
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) and its receptors play 
      important roles in the development and persistence of psoriatic plaques. The 
      antithyroid thioureylenes, propylthiouracil and methimazole, are effective in the 
      treatment of patients with psoriasis with a significant number of patients 
      showing clearing or near clearing of their lesions after a several weeks of 
      treatment. METHODS: The present study examined the effect of treatment with 
      propylthiouracil, given in a dose of 100 mg every 8 hours for 3 months, on the 
      serum levels of TNF-alpha in 9 patients with plaque psoriasis. RESULTS: 
      Propylthiouracil therapy did not result in a significant decline in serum 
      TNF-alpha concentrations. CONCLUSIONS: The findings suggest that the therapeutic 
      effect of propylthiouracil in psoriasis appears not to be related to any change 
      in the concentration of TNF-alpha but occurs via an anti-proliferative mechanism 
      as we have previously speculated.
FAU - Elias, Alan N
AU  - Elias AN
AD  - Department of Medicine, Division of Endocrinology and Metabolism, University of 
      California, Irvine Medical Center, 101 The City Drive, Orange, California 92868, 
      USA. anelias@uci.edu
FAU - Nanda, Vanda S
AU  - Nanda VS
FAU - Pandian, Raj
AU  - Pandian R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20040430
PL  - England
TA  - BMC Dermatol
JT  - BMC dermatology
JID - 100968541
RN  - 0 (Antimetabolites)
RN  - 0 (Antithyroid Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 721M9407IY (Propylthiouracil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antimetabolites/pharmacology/therapeutic use
MH  - Antithyroid Agents/pharmacology/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Propylthiouracil/pharmacology/*therapeutic use
MH  - Psoriasis/blood/*drug therapy
MH  - Tumor Necrosis Factor-alpha/*analysis
PMC - PMC419358
EDAT- 2004/05/04 05:00
MHDA- 2004/08/06 05:00
PMCR- 2004/04/30
CRDT- 2004/05/04 05:00
PHST- 2004/01/11 00:00 [received]
PHST- 2004/04/30 00:00 [accepted]
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/08/06 05:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
PHST- 2004/04/30 00:00 [pmc-release]
AID - 1471-5945-4-4 [pii]
AID - 10.1186/1471-5945-4-4 [doi]
PST - epublish
SO  - BMC Dermatol. 2004 Apr 30;4:4. doi: 10.1186/1471-5945-4-4.