PMID- 15120191
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 4
DP  - 2004 Apr
TI  - HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid 
      arthritis subgroups in Colombian mestizos.
PG  - 359-65
AB  - We studied the association of human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 
      alleles and HLA haplotypes with juvenile rheumatoid arthritis (JRA) in 65 
      patients and 65 controls from Colombia. The JRA subsets were distinguished on the 
      basis of criteria established by the American College of Rheumatology. Two 
      alleles were associated with protection, HLA-DRB1*1501 (p = 0.002) and 
      HLA-DRB1*1402 (p = 0.01). HLA-DRB1*1602 (p = 0.0000002) was associated with 
      susceptibility for systemic JRA and HLA-DRB1*1104 (p = 0.0002) for pauciarticular 
      JRA. Amino acid sequences at residues 70-74 of DRB1 chain shared by HLA-DRB1 
      alleles (shared epitomes) were also informative. The polyarticular JRA subset 
      revealed association with (70)QRRAA(74), which includes HLA-DRB1*04, 01, and 
      (70)DRRAA(74), which includes DRB1*1601, 1602, 1101, and 1104. Two new findings 
      of interest were the association of the haplotypes DRB1*1104, DQB1*0301(p = 
      0.0002) with pauciarticular JRA and DRB1*1602, DQB1*0301 (p = 0.0000002) 
      association with systemic JRA. The DRB1 alleles of these two haplotypes share the 
      epitope (70)DRRAA(74)and were associated with both the pauciarticular and the 
      systemic subset of JRA. Our results suggest that studies of disease 
      susceptibility in populations of admixed genetic background should take into 
      account the contribution of different ethnic groups or nationalities in the 
      recruitment of controls and patients studied in order to rule out genetic 
      stratification.
FAU - Garavito, Gloria
AU  - Garavito G
AD  - Immunology and Molecular Biology Laboratory, Universidad del Norte, Barranquilla, 
      Colombia. ggaravit@uninorte.edu.co
FAU - Yunis, Edmond J
AU  - Yunis EJ
FAU - Egea, Eduardo
AU  - Egea E
FAU - Ramirez, Luis A
AU  - Ramirez LA
FAU - Malagon, Clara
AU  - Malagon C
FAU - Iglesias, Antonio
AU  - Iglesias A
FAU - De La Cruz, Oscar F
AU  - De La Cruz OF
FAU - Uribe, Oscar
AU  - Uribe O
FAU - Navarro, Edgar
AU  - Navarro E
FAU - Martinez, Paz
AU  - Martinez P
FAU - Jaraquemada, Dolores
AU  - Jaraquemada D
LA  - eng
GR  - AL 29583/PHS HHS/United States
GR  - HL59838/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Epitopes)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
SB  - IM
MH  - Adolescent
MH  - *Alleles
MH  - Arthritis, Juvenile/diagnosis/etiology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Colombia/ethnology
MH  - Epitopes/genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - Genetic Markers
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Sequence Analysis, Protein
EDAT- 2004/05/04 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/05/04 05:00
PHST- 2003/09/02 00:00 [received]
PHST- 2004/01/27 00:00 [revised]
PHST- 2004/01/29 00:00 [accepted]
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
AID - S0198885904000345 [pii]
AID - 10.1016/j.humimm.2004.01.016 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Apr;65(4):359-65. doi: 10.1016/j.humimm.2004.01.016.